doi: 10.1021/acs.est.2c02896.
Epub 2022 Jul 25.
Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments
Evgenios Agathokleous
1
2
, Damià Barceló
3
4
, Michael Aschner
5
, Ricardo Antunes Azevedo
6
, Prosun Bhattacharya
7
, David Costantini
8
, G Christopher Cutler
9
, Alessandra De Marco
10
, Anca Oana Docea
11
, José G Dórea
12
, Stephen O Duke
13
, Thomas Efferth
14
, Despo Fatta-Kassinos
15
, Vasileios Fotopoulos
16
, Antonio Ginebreda
17
, Raul Narciso C Guedes
18
, A Wallace Hayes
19
20
, Ivo Iavicoli
21
, Olga-Ioanna Kalantzi
22
, Takayoshi Koike
23
, Demetrios Kouretas
24
, Manish Kumar
25
, José E Manautou
26
, Michael N Moore
27
28
29
, Elena Paoletti
30
, Josep Peñuelas
31
32
, Yolanda Picó
33
, Russel J Reiter
34
, Ramin Rezaee
35
36
, Jörg Rinklebe
37
, Teresa Rocha-Santos
38
, Pierre Sicard
39
, Christian Sonne
40
41
, Christopher Teaf
42
, Aristidis Tsatsakis
43
, Alexander I Vardavas
43
, Wenjie Wang
44
45
, Eddy Y Zeng
46
, Edward J Calabrese
47
Affiliations
Affiliations
- 1 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.
- 2 Research Center for Global Changes and Ecosystem Carbon Sequestration & Mitigation, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.
- 3 Institute of Environmental Assessment and Water Research, IDAEA-CSIC; Barcelona 08034, Spain.
- 4 Catalan Institute for Water Research, ICRA-CERCA; Girona 17003, Spain.
- 5 Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York 10461, United States.
- 6 Departamento de Genética, Escola Superior de Agricultura "Luiz de Queiroz"/Universidade de São Paulo (ESALQ/USP); São Paulo CEP 13418-900, Brazil.
- 7 KTH-international Groundwater Arsenic Research Group, Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology; Stockholm SE-100 44, Sweden.
- 8 Unité Physiologie Moléculaire et Adaptation (PhyMA), UMR 7221 Muséum National d'Histoire Naturelle; CNRS, 7 Rue Cuvier, 75005 Paris, France.
- 9 Department of Plant, Food, and Environmental Sciences, Agricultural Campus, Dalhousie University; Truro, Nova Scotia B2N 5E3, Canada.
- 10 ENEA, CR Casaccia, SSPT-PVS; Rome 00123, Italy.
- 11 Department of Toxicology, University of Medicine and Pharmacy of Craiova; Craiova 200349, Romania.
- 12 Faculdade de Ciências da Saúde, Universidade de Brasília; Brasília 70919-970, Brazil.
- 13 National Center for Natural Products Research, School of Pharmacy, University of Mississippi; Mississippi 38677, United States.
- 14 Johannes Gutenberg University, Institute of Pharmaceutical and Biomedical Sciences, Department of Pharmaceutical Biology; Mainz 55128, Germany.
- 15 Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus; P.O. Box 20537, Nicosia 1678, Cyprus.
- 16 Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology; Lemesos 3603, Cyprus.
- 17 Environmental Chemistry, IDAEA-CSIC, c/Jordi Girona 18-26, Barcelona 08034, Spain.
- 18 Departamento de Entomologia, Universidade Federal de Viçosa;Viçosa, Minas Gerais 36570-900, Brazil.
- 19 Center for Environmental/Occupational Risk Analysis & Management, University of South Florida, College of Public Health; Tampa, Florida 33612, United States.
- 20 Michigan State University; East Lansing, Michigan 48824, United States.
- 21 Department of Public Health, Section of Occupational Medicine, University of Naples Federico II; Naples 80131, Italy.
- 22 Department of Environment, University of the Aegean; Mytilene 81100, Greece.
- 23 Research Faculty of Agriculture, Hokkaido University; Sapporo, Hokkaido 060-8589, Japan.
- 24 Department of Biochemistry-Biotechnology, University of Thessaly, Larisa 41500, Greece.
- 25 School of Engineering, University of Petroleum and Energy Studies; Dehradun 248007, India.
- 26 Pharmaceutical Science, University of Connecticut, Storrs, Connecticut 06269, United States.
- 27 European Centre for Environment & Human Health (ECEHH), University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital; Truro TR1 3HD, U.K.
- 28 Plymouth Marine Laboratory; Plymouth, Devon PL1 3DH, U.K.
- 29 School of Biological & Marine Sciences, University of Plymouth; Plymouth PL 4 8AA, U.K.
- 30 Institute of Research on Terrestrial Ecosystems, National Research Council; Sesto Fiorentino 50019, Italy.
- 31 CSIC, Global Ecology Unit CREAF-CSIC-UAB; Bellaterra, Catalonia 08193, Spain.
- 32 CREAF; Cerdanyola del Vallès, Catalonia 08193, Spain.
- 33 Environmental and Food Safety Research Group (SAMA-UV), Desertification Research Centre (CIDE), Universitat de València-CSIC-GV; Valencia 46113, Spain.
- 34 Department of Cell Systems and Anatomy, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio; San Antonio, Texas 78229, United States.
- 35 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad 91779-43335, Iran.
- 36 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 91779-43335, Iran.
- 37 University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water, and Waste-Management, Laboratory of Soil, and Groundwater-Management; Wuppertal 42285, Germany.
- 38 Centre for Environmental and Marine Studies (CESAM) & Department of Chemistry, University of Aveiro; Aveiro 3810-193, Portugal.
- 39 ARGANS, 260 route du Pin Montard, Biot 06410, France.
- 40 Aarhus University, Department of Bioscience, Arctic Research Centre (ARC); Roskilde DK-4000, Denmark.
- 41 Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University; Zhengzhou 450002, China.
- 42 Institute of Science & Public Affairs, Florida State University; Tallahassee, Florida 32306, United States.
- 43 Laboratory of Toxicology, Medical School, University of Crete; Heraklion 71003, Greece.
- 44 Key Laboratory of Forest Plant Ecology, Northeast Forestry University; Harbin 150040, China.
- 45 Northeast Institute of Geography and Agroecology, Chinese Academy of Science; Changchun 130102, China.
- 46 Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University; Guangzhou 511443, China.
- 47 Department of Environmental Health Sciences, University of Massachusetts; Amherst, Massachusetts 01003, United States.
- PMID: 35878124
- DOI: 10.1021/acs.est.2c02896
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Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments
Evgenios Agathokleous et al.
Environ Sci Technol.
.
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doi: 10.1021/acs.est.2c02896.
Epub 2022 Jul 25.
Authors
Evgenios Agathokleous
1
2
, Damià Barceló
3
4
, Michael Aschner
5
, Ricardo Antunes Azevedo
6
, Prosun Bhattacharya
7
, David Costantini
8
, G Christopher Cutler
9
, Alessandra De Marco
10
, Anca Oana Docea
11
, José G Dórea
12
, Stephen O Duke
13
, Thomas Efferth
14
, Despo Fatta-Kassinos
15
, Vasileios Fotopoulos
16
, Antonio Ginebreda
17
, Raul Narciso C Guedes
18
, A Wallace Hayes
19
20
, Ivo Iavicoli
21
, Olga-Ioanna Kalantzi
22
, Takayoshi Koike
23
, Demetrios Kouretas
24
, Manish Kumar
25
, José E Manautou
26
, Michael N Moore
27
28
29
, Elena Paoletti
30
, Josep Peñuelas
31
32
, Yolanda Picó
33
, Russel J Reiter
34
, Ramin Rezaee
35
36
, Jörg Rinklebe
37
, Teresa Rocha-Santos
38
, Pierre Sicard
39
, Christian Sonne
40
41
, Christopher Teaf
42
, Aristidis Tsatsakis
43
, Alexander I Vardavas
43
, Wenjie Wang
44
45
, Eddy Y Zeng
46
, Edward J Calabrese
47
Affiliations
- 1 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.
- 2 Research Center for Global Changes and Ecosystem Carbon Sequestration & Mitigation, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China.
- 3 Institute of Environmental Assessment and Water Research, IDAEA-CSIC; Barcelona 08034, Spain.
- 4 Catalan Institute for Water Research, ICRA-CERCA; Girona 17003, Spain.
- 5 Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York 10461, United States.
- 6 Departamento de Genética, Escola Superior de Agricultura "Luiz de Queiroz"/Universidade de São Paulo (ESALQ/USP); São Paulo CEP 13418-900, Brazil.
- 7 KTH-international Groundwater Arsenic Research Group, Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology; Stockholm SE-100 44, Sweden.
- 8 Unité Physiologie Moléculaire et Adaptation (PhyMA), UMR 7221 Muséum National d'Histoire Naturelle; CNRS, 7 Rue Cuvier, 75005 Paris, France.
- 9 Department of Plant, Food, and Environmental Sciences, Agricultural Campus, Dalhousie University; Truro, Nova Scotia B2N 5E3, Canada.
- 10 ENEA, CR Casaccia, SSPT-PVS; Rome 00123, Italy.
- 11 Department of Toxicology, University of Medicine and Pharmacy of Craiova; Craiova 200349, Romania.
- 12 Faculdade de Ciências da Saúde, Universidade de Brasília; Brasília 70919-970, Brazil.
- 13 National Center for Natural Products Research, School of Pharmacy, University of Mississippi; Mississippi 38677, United States.
- 14 Johannes Gutenberg University, Institute of Pharmaceutical and Biomedical Sciences, Department of Pharmaceutical Biology; Mainz 55128, Germany.
- 15 Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus; P.O. Box 20537, Nicosia 1678, Cyprus.
- 16 Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology; Lemesos 3603, Cyprus.
- 17 Environmental Chemistry, IDAEA-CSIC, c/Jordi Girona 18-26, Barcelona 08034, Spain.
- 18 Departamento de Entomologia, Universidade Federal de Viçosa;Viçosa, Minas Gerais 36570-900, Brazil.
- 19 Center for Environmental/Occupational Risk Analysis & Management, University of South Florida, College of Public Health; Tampa, Florida 33612, United States.
- 20 Michigan State University; East Lansing, Michigan 48824, United States.
- 21 Department of Public Health, Section of Occupational Medicine, University of Naples Federico II; Naples 80131, Italy.
- 22 Department of Environment, University of the Aegean; Mytilene 81100, Greece.
- 23 Research Faculty of Agriculture, Hokkaido University; Sapporo, Hokkaido 060-8589, Japan.
- 24 Department of Biochemistry-Biotechnology, University of Thessaly, Larisa 41500, Greece.
- 25 School of Engineering, University of Petroleum and Energy Studies; Dehradun 248007, India.
- 26 Pharmaceutical Science, University of Connecticut, Storrs, Connecticut 06269, United States.
- 27 European Centre for Environment & Human Health (ECEHH), University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital; Truro TR1 3HD, U.K.
- 28 Plymouth Marine Laboratory; Plymouth, Devon PL1 3DH, U.K.
- 29 School of Biological & Marine Sciences, University of Plymouth; Plymouth PL 4 8AA, U.K.
- 30 Institute of Research on Terrestrial Ecosystems, National Research Council; Sesto Fiorentino 50019, Italy.
- 31 CSIC, Global Ecology Unit CREAF-CSIC-UAB; Bellaterra, Catalonia 08193, Spain.
- 32 CREAF; Cerdanyola del Vallès, Catalonia 08193, Spain.
- 33 Environmental and Food Safety Research Group (SAMA-UV), Desertification Research Centre (CIDE), Universitat de València-CSIC-GV; Valencia 46113, Spain.
- 34 Department of Cell Systems and Anatomy, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio; San Antonio, Texas 78229, United States.
- 35 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad 91779-43335, Iran.
- 36 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 91779-43335, Iran.
- 37 University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water, and Waste-Management, Laboratory of Soil, and Groundwater-Management; Wuppertal 42285, Germany.
- 38 Centre for Environmental and Marine Studies (CESAM) & Department of Chemistry, University of Aveiro; Aveiro 3810-193, Portugal.
- 39 ARGANS, 260 route du Pin Montard, Biot 06410, France.
- 40 Aarhus University, Department of Bioscience, Arctic Research Centre (ARC); Roskilde DK-4000, Denmark.
- 41 Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University; Zhengzhou 450002, China.
- 42 Institute of Science & Public Affairs, Florida State University; Tallahassee, Florida 32306, United States.
- 43 Laboratory of Toxicology, Medical School, University of Crete; Heraklion 71003, Greece.
- 44 Key Laboratory of Forest Plant Ecology, Northeast Forestry University; Harbin 150040, China.
- 45 Northeast Institute of Geography and Agroecology, Chinese Academy of Science; Changchun 130102, China.
- 46 Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University; Guangzhou 511443, China.
- 47 Department of Environmental Health Sciences, University of Massachusetts; Amherst, Massachusetts 01003, United States.
- PMID: 35878124
- DOI: 10.1021/acs.est.2c02896
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Keywords: Chemical Risk Assessments; cancer; hormesis.
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