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. 2022 Aug 31;20(3):573-577.
doi: 10.9758/cpn.2022.20.3.573.

The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea

Gyurin Kim  1 , Soo Jung Rim  1 , Minkyung Jo  1 , Min Geu Lee  1 , Se Jin Park  1 , Subin Park  2
Affiliations

The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea

Gyurin Kim et al. Clin Psychopharmacol Neurosci. .

Abstract

Objective: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia.

Methods: We analyzed data from the Korean National Health Insurance System-National Sample Cohort covering the 2002-2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high).

Results: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia.

Conclusion: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.

Keywords: Antipsychotics; Mortality; Schizophrenia; South Korea.

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Conflict of interest statement

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

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