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Multicenter Study
. 2022 Nov;25(6):1031-1038.
doi: 10.1007/s10120-022-01323-8. Epub 2022 Jul 25.

The feasibility and safety of endoscopic submucosal dissection of gastric lesions larger than 5 cm

Hideyuki Chiba  1 , Ken Ohata  2 , Jun Tachikawa  3 , Keiji Yamada  4 , Mikio Kobayashi  4 , Naoya Okada  4 , Jun Arimoto  4 , Hiroki Kuwabara  4 , Michiko Nakaoka  4 , Keiichi Ashikari  5 , Yohei Minato  2 , Tohru Goto  4
Affiliations
Multicenter Study

The feasibility and safety of endoscopic submucosal dissection of gastric lesions larger than 5 cm

Hideyuki Chiba et al. Gastric Cancer. 2022 Nov.

Abstract

Background: As the indications for endoscopic submucosal dissection (ESD) for early gastric cancer have been revised, diagnostic ESD has increased. However, despite the technical difficulty of ESD for large lesions, the degree to which curative resection can be achieved has not been clarified. This study investigated the feasibility and safety of ESD for gastric lesions larger than 5 cm.

Methods: This retrospective multicenter study included 3474 gastric lesions treated by ESD from April 2012 to December 2021. We compared clinicopathological characteristics and treatment outcomes between lesions ≥ 5 cm and lesions < 5 cm.

Results: There were 128 lesions in the ≥ 5 cm group and 3282 lesions in the < 5 cm group. In the ≥ 5 cm group, upper location and fibrosis during ESD were more common, with a lower rate of 0-IIc type. Both en bloc resection rate and R0 resection rate were comparable, but there was a difference in curative resection rate (65.6% in the ≥ 5 cm group and 91.5% in the < 5 cm group). The frequency of adverse events (post-ESD bleeding, perforation, or stenosis) was almost similar, but delayed perforation was significantly more common (1.6% in the ≥ 5 cm group vs. 0.1% in the < 5 cm group).

Conclusions: About two-thirds of curative resections were obtained with ESD for early gastric lesions larger than 5 cm, but delayed complications should be noted (Number: UMIN000047725).

Keywords: Endoscopic submucosal dissection; Gastric cancer; Gastric neoplasm.

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