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. 2023 Aug;14(4):435-437.
doi: 10.1007/s12975-022-01069-6. Epub 2022 Jul 26.

Significance of Microglial Energy Metabolism in Maintaining Brain Homeostasis

John P Bielanin  1   2 , Dandan Sun  3   4   5   6
Affiliations

Significance of Microglial Energy Metabolism in Maintaining Brain Homeostasis

John P Bielanin et al. Transl Stroke Res. 2023 Aug.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The metabolic homeostasis between OxPHOS and glycolysis is important for microglial function. Under physiological conditions, microglia primarily rely on OxPHOS for ATP production. In response to inflammatory stimulation, microglia undergo metabolic reprogramming to switch from OxPHOS to glycolysis. Metabolic reprograming was characterized by an increase in glycolysis, tricarboxylic acid (TCA) metabolite accumulation, hypoxia-inducible factor-1 α (HIF-1α), and mammalian target of rapamycin (mTOR) transcriptional control, and by a decrease in mitochondrial respiration, which subsequently regulates phagocytosis and cytokine production, etc. This figure was created with Adobe Illustrator software (Adobe Inc., Mountain View, CA USA). Abbreviations: OxPHOS, oxidative phosphorylation; TCA, tricarboxylic acid; LPS, lipopolysaccharide; IL-1β, interleukin-1β; IFN-γ, interferon-γ; TLR, toll-like receptor; TRPV1R, transient receptor potential vanilloid type 1 receptor; mTOR, mammalian target of rapamycin; HIF1-1α, hypoxia inducible factor-1α; GLUT 1, glucose transporter 1; HK, hexokinase; PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; TNF-α, tumor necrosis factor-α
See this image and copyright information in PMC

References

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