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. 2022 Jul 18:14:879-888.
doi: 10.2147/CLEP.S361910. eCollection 2022.

Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau  1 , Signe Bollerup  1 , Frederik Engsig  1 , Henrik Krarup  2 , Lone Hagens Mygind  3 , Jesper Bach Hansen  3 , Lone Galmstrup Madsen  4   5 , Peter Thielsen  6 , Ulla Balslev  7 , Lars Nørregaard Nielsen  8 , Toke S Barfod  9 , Mette Rye Clausen  10 , Lise Hobolth  11 , Alex Lund Laursen  12 , Britta Tarp  13 , Birgit T Roege  14 , Jan Gerstoft  15 , Peer Brehm Christensen  16   17 , Nina Weis  1   5
Affiliations

Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Frederik Faergemann Lau et al. Clin Epidemiol. .

Abstract

Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

Study design and setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

Keywords: atherosclerosis; cardiovascular disease; coronary heart disease; general population; hepatitis B virus; ischemic heart disease; viral infection.

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Conflict of interest statement

NW has been a clinical investigator, lecturer or member of advisory boards for AbbVie, GSK, MSD. Gilead and has received unrestricted grants for research from AbbVie and Gilead, with no relation to the present work. PBC has received unrestricted grants for research from AbbVie, Gilead, and MSD, not related to this study. FE reports personal fees from MSD, during the conduct of the study. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of inclusion of persons infected with chronic hepatitis B virus.
Figure 2
Figure 2
Cumulative incidence function plot of ischemic heart disease events and death in patients with chronic hepatitis B (cases) and sex- and age-matched individuals without chronic hepatitis B from the general population (control-persons). IHD, Blue; Death, black; Control, solid line; Case, dashed line.
See this image and copyright information in PMC

References

    1. Beasley RP. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer. 1988;61(10):1942–1956. doi:10.1002/1097-0142(19880515)61:10<1942::aid-cncr2820611003>3.0.co;2-j - DOI - PubMed
    1. Seto WK, Lo YR, Pawlotsky JM, Yuen MF. Chronic hepatitis B virus infection. Lancet. 2018;392(10161):2313–2324. doi:10.1016/S0140-6736(18)31865-8 - DOI - PubMed
    1. Andersen E, Omland L, Jepsen P, et al. Risk of all-type cancer, hepatocellular carcinoma, non-Hodgkin lymphoma and pancreatic cancer in patients infected with hepatitis B virus. J Viral Hepat. 2015;22(10):828–834. doi:10.1111/jvh.12391 - DOI - PubMed
    1. Amin J, Dore GJ, O’Connell DL, et al. Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. J Hepatol. 2006;45(2):197–203. doi:10.1016/j.jhep.2006.02.014 - DOI - PubMed
    1. Ganem D, Prince AM. Hepatitis B virus infection–natural history and clinical consequences. N Engl J Med. 2004;350(11):1118–1129. doi:10.1056/NEJMra031087 - DOI - PubMed

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