From "organs on a chip" to "patient on a chip"

doi:10.1016/j.xinn.2022.100282

. 2022 Jul 6;3(5):100282.

doi: 10.1016/j.xinn.2022.100282. eCollection 2022 Sep 13.

From "organs on a chip" to "patient on a chip"

Qimanguli Saiding^{1

2}, Jingyun Ma¹, Chunhai Ke¹, Wenguo Cui²

Affiliations

¹ Ningbo Institute of Innovation for Combined Medicine and Engineering, Ningbo Medical Center Li Huili Hospital, 57 Xingning Road, Ningbo, Zhejiang 315100, China.
² Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.

PMID: 35880236
PMCID: PMC9307665
DOI: 10.1016/j.xinn.2022.100282

From "organs on a chip" to "patient on a chip"

Qimanguli Saiding et al. Innovation (Camb). 2022.

. 2022 Jul 6;3(5):100282.

doi: 10.1016/j.xinn.2022.100282. eCollection 2022 Sep 13.

Authors

Qimanguli Saiding^{1

2}, Jingyun Ma¹, Chunhai Ke¹, Wenguo Cui²

Affiliations

¹ Ningbo Institute of Innovation for Combined Medicine and Engineering, Ningbo Medical Center Li Huili Hospital, 57 Xingning Road, Ningbo, Zhejiang 315100, China.
² Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.

PMID: 35880236
PMCID: PMC9307665
DOI: 10.1016/j.xinn.2022.100282

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

**Figure 1**
Multi-organ tissue chip system Left: illustration of patient-on-a-chip model. Middle: the patient-derived human induced pluripotent stem cell-induced mature tissue niches are linked by recirculating vascular flow to allow for the recapitulation of interdependent organ functions. Each individual tissue is cultured in its compartment and is separated from the recirculating vascular flow by a selectively permeable endothelial barrier. Right: the interlinked tissues recapitulated the pharmacokinetic and pharmacodynamic profiles of doxorubicin in humans.

See this image and copyright information in PMC

Cited by

A Biomimetic Optical Cardiac Fibrosis-on-a-Chip for High-Throughput Anti-Fibrotic Drug Screening.
Shang Y, Xu D, Sun L, Zhao Y, Sun L. Shang Y, et al. Research (Wash D C). 2024 Sep 12;7:0471. doi: 10.34133/research.0471. eCollection 2024. Research (Wash D C). 2024. PMID: 39268502 Free PMC article.
Prototyping in Polymethylpentene to Enable Oxygen-Permeable On-a-Chip Cell Culture and Organ-on-a-Chip Devices Suitable for Microscopy.
Sønstevold L, Koza P, Czerkies M, Andreassen E, McMahon P, Vereshchagina E. Sønstevold L, et al. Micromachines (Basel). 2024 Jul 10;15(7):898. doi: 10.3390/mi15070898. Micromachines (Basel). 2024. PMID: 39064409 Free PMC article.
Animal Models in Diabetic Research-History, Presence, and Future Perspectives.
Pandey S, Chmelir T, Chottova Dvorakova M. Pandey S, et al. Biomedicines. 2023 Oct 20;11(10):2852. doi: 10.3390/biomedicines11102852. Biomedicines. 2023. PMID: 37893225 Free PMC article. Review.
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Qin X, Guo J, Li H, He H, Cai F, Chen X, Chen M, Chen T, Ma L. Qin X, et al. Adv Sci (Weinh). 2025 Apr;12(14):e2412062. doi: 10.1002/advs.202412062. Epub 2025 Feb 14. Adv Sci (Weinh). 2025. PMID: 39950936 Free PMC article.
Single neurons on microelectrode array chip: manipulation and analyses.
Zhang H, Wang P, Huang N, Zhao L, Su Y, Li L, Bian S, Sawan M. Zhang H, et al. Front Bioeng Biotechnol. 2023 Sep 27;11:1258626. doi: 10.3389/fbioe.2023.1258626. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37829565 Free PMC article.

See all "Cited by" articles

References

1. Prasad V., Mailankody S. Research and development spending to bring a single cancer drug to market and revenues after approval. JAMA. Intern. Med. 2017;177:1569–1575. - PMC - PubMed
1. Clevers H. Modeling development and disease with organoids. Cell. 2016;165:1586–1597. - PubMed
1. Liu H., Wang Y., Cui K., et al. Advances in hydrogels in organoids and Organs-on-a-Chip. Adv. Mater. 2019;31 - PubMed
1. Ronaldson-Bouchard K., Teles D., Yeager K., et al. A multi-organ chip with matured tissue niches linked by vascular flow. Nat. Biomed. Eng. 2022;6:351–371. - PMC - PubMed
1. Vunjak-Novakovic G., Ronaldson-Bouchard K., Radisic M. Organs-on-a-chip models for biological research. Cell. 2021;184:4597–4611. - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources

[1] Prasad V., Mailankody S. Research and development spending to bring a single cancer drug to market and revenues after approval. JAMA. Intern. Med. 2017;177:1569–1575. - PMC - PubMed

[2] Prasad V., Mailankody S. Research and development spending to bring a single cancer drug to market and revenues after approval. JAMA. Intern. Med. 2017;177:1569–1575. - PMC - PubMed

[3] Clevers H. Modeling development and disease with organoids. Cell. 2016;165:1586–1597. - PubMed

[4] Clevers H. Modeling development and disease with organoids. Cell. 2016;165:1586–1597. - PubMed

[5] Liu H., Wang Y., Cui K., et al. Advances in hydrogels in organoids and Organs-on-a-Chip. Adv. Mater. 2019;31 - PubMed

[6] Liu H., Wang Y., Cui K., et al. Advances in hydrogels in organoids and Organs-on-a-Chip. Adv. Mater. 2019;31 - PubMed

[7] Ronaldson-Bouchard K., Teles D., Yeager K., et al. A multi-organ chip with matured tissue niches linked by vascular flow. Nat. Biomed. Eng. 2022;6:351–371. - PMC - PubMed

[8] Ronaldson-Bouchard K., Teles D., Yeager K., et al. A multi-organ chip with matured tissue niches linked by vascular flow. Nat. Biomed. Eng. 2022;6:351–371. - PMC - PubMed

[9] Vunjak-Novakovic G., Ronaldson-Bouchard K., Radisic M. Organs-on-a-chip models for biological research. Cell. 2021;184:4597–4611. - PMC - PubMed

[10] Vunjak-Novakovic G., Ronaldson-Bouchard K., Radisic M. Organs-on-a-chip models for biological research. Cell. 2021;184:4597–4611. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

From "organs on a chip" to "patient on a chip"

Affiliations

From "organs on a chip" to "patient on a chip"

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources