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Review
. 2022 Sep 1;75(5):117-122.
doi: 10.33588/rn.7505.2022207.

[Myasthenia gravis and pregnancy: impact and approach]

[Article in Spanish]
K Alfaro-Paredes  1 , C Aguilar-Ydiáquez  1 , R Aguirre-Flores  1 , H Schulz-Cáceres  2
Affiliations
Review

[Myasthenia gravis and pregnancy: impact and approach]

[Article in Spanish]
K Alfaro-Paredes et al. Rev Neurol. .

Abstract
in English, Spanish

Introduction: Myasthenia gravis is characterized by skeletal muscle weakness, the most common initial presentation includes ocular weakness with asymmetric ptosis and binocular diplopia. Around 19-50% of pregnant women with myasthenia gravis will experience a worsening of the disease. The objective of this article was to review the current information regarding the interrelation between MG and pregnancy; as well as its approach.

Development: Bibliographic search in databases such as PubMed, ScienceDirect, SciELO, Google Scholar and medRxiv. Original articles, reviews, series and case reports between 2013 and 2022 are included.

Conclusions: Myasthenia gravis would not significantly effects on pregnancy; however, pregnancy can exacerbate the disease, especially during the first trimester or after delivery. The approach to pregnant women with myasthenia gravis must be multidisciplinary and involves the adjustment of pharmacological treatment and constant monitoring.

Title: Miastenia gravis y embarazo: impacto y abordaje.

Introducción. La miastenia gravis (MG) se caracteriza por debilidad del músculo esquelético, que es la presentación inicial más común, debilidad ocular con ptosis asimétrica y diplopía binocular. Alrededor del 19-50% de las gestantes con MG experimentará un empeoramiento de la enfermedad. El objetivo de este artículo fue revisar la información actual respecto a la interrelación entre la MG y el embarazo, así como su abordaje. Desarrollo. Se realizó una búsqueda bibliográfica en bases de datos como PubMed, ScienceDirect, SciELO, Google Scholar y medRxiv. Se incluyeron artículos originales, de revisión, series e informes de casos comprendidos entre 2013 y 2022. Conclusiones. La MG no afectaría significativamente al embarazo; sin embargo, el embarazo puede exacerbar la enfermedad, principalmente durante el primer trimestre o después del parto. El abordaje de la gestante con MG debe ser multidisciplinario e implica el ajuste del tratamiento farmacológico y un seguimiento constante.

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Conflict of interest statement

Conflicto de intereses: Los autores no comunican conflictos de interés durante la elaboración de la investigación.

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