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. 2020 Oct 7;12(Suppl1):20190015.
doi: 10.1515/scid-2019-0015. eCollection 2020 Sep 1.

Errors in multiple variables in human immunodeficiency virus (HIV) cohort and electronic health record data: statistical challenges and opportunities

Bryan E Shepherd  1 , Pamela A Shaw  2
Affiliations

Errors in multiple variables in human immunodeficiency virus (HIV) cohort and electronic health record data: statistical challenges and opportunities

Bryan E Shepherd et al. Stat Commun Infect Dis. .

Abstract

Objectives: Observational data derived from patient electronic health records (EHR) data are increasingly used for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) research. There are challenges to using these data, in particular with regards to data quality; some are recognized, some unrecognized, and some recognized but ignored. There are great opportunities for the statistical community to improve inference by incorporating validation subsampling into analyses of EHR data.Methods: Methods to address measurement error, misclassification, and missing data are relevant, as are sampling designs such as two-phase sampling. However, many of the existing statistical methods for measurement error, for example, only address relatively simple settings, whereas the errors seen in these datasets span multiple variables (both predictors and outcomes), are correlated, and even affect who is included in the study.Results/Conclusion: We will discuss some preliminary methods in this area with a particular focus on time-to-event outcomes and outline areas of future research.

Keywords: HIV; electronic health records; measurement error; misclassification; two-phase sampling.

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Conflict of interest statement

Competing interests: Authors state no conflict of interest.

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