Mechanics drive lymph node expansion

Yunus Alapan^{1

2}, Susan N Thomas^{3

4

5

6}

Affiliations

¹ George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
² Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
³ George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁴ Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁵ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁶ Winship Cancer Institute, Emory University, Atlanta, GA, USA. susan.thomas@gatech.edu.

Comment

Yunus Alapan et al. Nat Immunol. 2022 Aug.

. 2022 Aug;23(8):1139-1141.

doi: 10.1038/s41590-022-01277-0.

Yunus Alapan^{1

2}, Susan N Thomas^{3

4

5

6}

¹ George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
² Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
³ George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁴ Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁵ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. susan.thomas@gatech.edu.
⁶ Winship Cancer Institute, Emory University, Atlanta, GA, USA. susan.thomas@gatech.edu.

No abstract available

Comment on

Multitier mechanics control stromal adaptations in the swelling lymph node.
Assen FP, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann WA, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg CP, Weninger W, Hannezo E, Luther SA, Stein JV, Sixt M. Assen FP, et al. Nat Immunol. 2022 Aug;23(8):1246-1255. doi: 10.1038/s41590-022-01257-4. Epub 2022 Jul 11. Nat Immunol. 2022. PMID: 35817845 Free PMC article.
Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics.
Horsnell HL, Tetley RJ, De Belly H, Makris S, Millward LJ, Benjamin AC, Heeringa LA, de Winde CM, Paluch EK, Mao Y, Acton SE. Horsnell HL, et al. Nat Immunol. 2022 Aug;23(8):1169-1182. doi: 10.1038/s41590-022-01272-5. Epub 2022 Jul 26. Nat Immunol. 2022. PMID: 35882934 Free PMC article.

1. Assen, F. P. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01257-4 (2022). - DOI - PubMed
1. Horsnell, H. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01272-5 (2022). - DOI - PubMed
1. Krishnamurty, A. T. & Turley, S. J. Nat. Immunol. 21, 369–380 (2020). - DOI
1. O'Melia, M. J., Lund, A. W. & Thomas, S. N. iScience 22, 28–43 (2019). - DOI
1. Acton, S. E. et al. Nature 514, 498–502 (2014). - DOI