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Review
. 2022 Jul 18;11(14):2232.
doi: 10.3390/cells11142232.

Emergence of Edible Plant-Derived Nanovesicles as Functional Food Components and Nanocarriers for Therapeutics Delivery: Potentials in Human Health and Disease

Sora Q Kim  1 , Kee-Hong Kim  2
Affiliations
Review

Emergence of Edible Plant-Derived Nanovesicles as Functional Food Components and Nanocarriers for Therapeutics Delivery: Potentials in Human Health and Disease

Sora Q Kim et al. Cells. .

Abstract

Extracellular vesicles (EVs) are a highly heterogeneous population of membranous particles that are secreted by almost all types of cells across different domains of life, including plants. In recent years, studies on plant-derived nanovesicles (PDNVs) showed that they could modulate metabolic reactions of the recipient cells, affecting (patho)physiology with health benefits in a trans-kingdom manner. In addition to its bioactivity, PDNV has advantages over conventional nanocarriers, making its application promising for therapeutics delivery. Here, we discuss the characteristics of PDNV and highlight up-to-date pre-clinical and clinical evidence, focusing on therapeutic application.

Keywords: exosomes; extracellular vesicles; food components; functional foods; phytochemicals; plant-derived nanovesicles; therapy; trans-kingdom interaction.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The number of publications per year in PubMed (https://pubmed.ncbi.nlm.nih.gov/ accessed on 1 June 2022) from 1972 to 2021 (as of May 2022). The field of PDNVs has evolved exponentially as shown by the number of publications searched by “plant extracellular vesicles OR plant nanovesicles”.
Figure 2
Figure 2
Unmodified PDNVs and modified PDNVs possess various potential health benefits.
See this image and copyright information in PMC

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