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Review
. 2022 Jul 18;11(14):2234.
doi: 10.3390/cells11142234.

MicroRNAs and Long Non-Coding RNAs in Adrenocortical Carcinoma

Mario Detomas  1 , Claudia Pivonello  2 , Bianca Pellegrini  2 , Laura-Sophie Landwehr  1 , Silviu Sbiera  1 , Rosario Pivonello  2   3 , Cristina L Ronchi  1   4   5 , Annamaria Colao  2   3 , Barbara Altieri  1 , Maria Cristina De Martino  2
Affiliations
Review

MicroRNAs and Long Non-Coding RNAs in Adrenocortical Carcinoma

Mario Detomas et al. Cells. .

Abstract

Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, still characterized by high mortality and morbidity due to both endocrine and oncological complications. Despite the rarity of this disease, recently, the role of ncRNA has been quite extensively evaluated in ACC. In order to better explore the role of the ncRNA in human ACC, this review summarizes the current knowledge on ncRNA dysregulation in ACC and its potential role in the diagnosis, treatment, and management of this tumor.

Keywords: ACC; adrenocortical adenoma; adrenocortical tumor; lncRNA; miRNA; prognostic markers.

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Conflict of interest statement

The authors declare no potential conflict of interest.

Figures

Figure 1
Figure 1
The image depicts the tumorigenesis pathways in which the principal miRNAs are involved in ACC pathogenesis. Dotted red lines represent the potential pathways regulated by miRNAs evaluated in other types of cancer. Continuous red lines represent the pathways regulated by miRNAs evaluated in ACC models. Image created with BioRender.com.
See this image and copyright information in PMC

References

    1. Fassnacht M., Dekkers O.M., Else T., Baudin E., Berruti A., de Krijger R., Haak H.R., Mihai R., Assie G., Terzolo M. European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors. Eur. J. Endocrinol. 2018;179:G1–G46. doi: 10.1530/EJE-18-0608. - DOI - PubMed
    1. Altieri B., Ronchi C.L., Kroiss M., Fassnacht M. Next-generation therapies for adrenocortical carcinoma. Best Pract. Res. Clin. Endocrinol. Metab. 2020;34:101434. doi: 10.1016/j.beem.2020.101434. - DOI - PubMed
    1. Giordano T.J., Berney D., de Krijger R.R., Erickson L., Fassnacht M., Mete O., Papathomas T., Papotti M., Sasano H., Thompson L.D.R., et al. Data set for reporting of carcinoma of the adrenal cortex: Explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Hum. Pathol. 2021;110:50–61. doi: 10.1016/j.humpath.2020.10.001. - DOI - PubMed
    1. Mete O., Erickson L.A., Juhlin C.C., de Krijger R.R., Sasano H., Volante M., Papotti M.G. Overview of the 2022 WHO Classification of Adrenal Cortical Tumors. Endocr. Pathol. 2022;33:155–196. doi: 10.1007/s12022-022-09710-8. - DOI - PMC - PubMed
    1. Mete O., Gucer H., Kefeli M., Asa S.L. Diagnostic and Prognostic Biomarkers of Adrenal Cortical Carcinoma. Am. J. Surg. Pathol. 2018;42:201–213. doi: 10.1097/PAS.0000000000000943. - DOI - PubMed

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