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Case Reports
. 2022 Jul 1;9(7):993.
doi: 10.3390/children9070993.

Adenomesenteritis following SARS-CoV-2 Vaccination in Children: A Case Report and Review of The Literature

Silvia Bloise  1 , Alessia Marcellino  1 , Vanessa Martucci  1 , Mariateresa Sanseviero  1 , Alessia Testa  1 , Emanuela Del Giudice  1 , Mattia Spatuzzo  1 , Daniel Sermoneta  2 , Flavia Ventriglia  1 , Riccardo Lubrano  1
Affiliations
Case Reports

Adenomesenteritis following SARS-CoV-2 Vaccination in Children: A Case Report and Review of The Literature

Silvia Bloise et al. Children (Basel). .

Abstract

At present, the vaccine authorized in children aged 5 years and older is the BNT162b2 messenger RNA COVID-19 vaccine. Unlike adults, there is limited data available in the pediatric age describing adverse events after vaccine. We report a case of adenomesenteritis in a young girl following the first dose of vaccine.

Keywords: SARS-CoV-2; adverse event; children; lymphadenopathy; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Increased size lymph nodes of reactive appearance in mesenteral location.
Figure 2
Figure 2
Resolution of intestinal inflammation.
Figure 3
Figure 3
Pathogenetic hypothesis related to COVID-19 post-vaccine adenomesenteritis: The administration of the m-RNA vaccine results in spike protein expression. Spike protein receptors are numerous at the level of enterocytes. The vaccination could act as a trigger and cause an immune-mediated inflammatory response in the gastrointestinal tract resulting in the adenomesenteritis. The figure was created in BioRender.com (accessed on 17 June 2022).
See this image and copyright information in PMC

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