Compression induced damage on in-situ severed and intact nerves

Abstract

The effect of rapid as well as sustained compressive forces applied to the surface of intact and severed peroneal nerves of rabbits was studied. Considerable effort was taken to ensure a quantitative and consistent experimental paradigm. Stimuli were delivered to the sciatic nerve, and the compound action potential was recorded in the peroneal nerve, with compressive forces applied more proximally on the peroneal nerve. It was found that the conduction of action potentials on the larger nerve fibers was more sensitive to compressive force than that of the smaller nerve fibers, although all nerve fibers stopped conducting when sufficient compression was applied to the nerve. The effect on the conduction of action potentials on the nerve fibers appeared to be determined both by Laplace's law (as previously reported by others) and the viscoelastic properties of the entire nerve. Relatively low compressive forces (20 gm applied over approximately 7 sq mm) were found to decrease the neutral conduction of the larger nerve fibers for at least two hours, whereas stagnation of blood circulation was not found to affect measurably the neural conduction of all the nerve fibers for up to two hours.