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Review
. 2022 Jul 11;10(7):1662.
doi: 10.3390/biomedicines10071662.

Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective

Kohei Matsuoka  1 , Mizuki Yamada  1 , Mitsuo Sato  1 , Kazuhide Sato  2   3   4
Affiliations
Review

Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective

Kohei Matsuoka et al. Biomedicines. .

Abstract

The conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for thoracic tumors has long been used as an alternative; conventional light therapy also called photodynamic therapy (PDT) has been used mainly for early-stage lung cancer. Recently, near-infrared photoimmunotherapy (NIR-PIT), which is a completely different concept from conventional PDT, has been developed and approved in Japan for the treatment of recurrent and previously treated head and neck cancer because of its specificity and effectiveness. NIR-PIT can apply to any target by changing to different antigens. In recent years, it has become clear that various specific and promising targets are highly expressed in thoracic tumors. In combination with these various specific targets, NIR-PIT is expected to be an ideal therapeutic approach for thoracic tumors. Additionally, techniques are being developed to further develop NIR-PIT for clinical practice. In this review, NIR-PIT is introduced, and its potential therapeutic applications for thoracic cancers are described.

Keywords: NIR-PIT; lung cancer; near-infrared photoimmunotherapy; phototherapy; target antigens; thoracic tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of near-infrared photoimmunotherapy. The conjugates, consisting of humanized monoclonal antibody and photo absorber IR700DX, can target specific cancer cell antigens. Once NIR-light irradiates, the targeting cancer cells are ruptured.
See this image and copyright information in PMC

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