Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 20;12(7):1759.
doi: 10.3390/diagnostics12071759.

Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

Narcisa Muresu  1 , Biagio Di Lorenzo  2 , Laura Saderi  2 , Illari Sechi  1 , Arcadia Del Rio  3 , Andrea Piana  1 , Giovanni Sotgiu  2
Affiliations
Review

Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

Narcisa Muresu et al. Diagnostics (Basel). .

Abstract

The etiology of bladder cancer is known to be associated with behavioral and environmental factors. Moreover, several studies suggested a potential role of HPV infection in the pathogenesis with controversial results. A systematic review was conducted to assess the role of HPV. A total of 46 articles that reported the prevalence of HPV infection in squamous (SCC), urothelial (UC), and transitional cell carcinomas (TCC) were selected. A pooled prevalence of 19% was found, with a significant difference in SCC that was mainly driven by HPV-16. Moreover, infection prevalence in case-control studies showed a higher risk of bladder cancer in HPV-positive cases (OR: 7.84; p-value < 0.00001). The results may suggest an etiologic role of HPV in bladder cancer. HPV vaccine administration in both sexes could be key to prevent the infection caused by high-risk genotypes.

Keywords: HPV; HPV detection; bladder cancer; human papillomavirus; transitional cell carcinoma; urothelial carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2020 flow diagram for new systematic reviews, which included searches of databases and registers only.
Figure 2
Figure 2
Forest plot of HPV pooled prevalence in bladder cancer. Adapted from [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59].
Figure 3
Figure 3
Forest plot of overall odds ratio in case-control studies. Adapted from [14,19,20,32,37,42,47,49,50,53,54].
See this image and copyright information in PMC

References

    1. International Agency for Reasearch on Cancer (IARC) Global Cancer Observatory. [(accessed on 18 May 2022)]. Available online: https://gco.iarc.fr.
    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Prout G.R., Jr., Wesley M.N., Greenberg R.S., Chen V.W., Brown C.C., Miller A.W., Weinstein R.S., Robboy S.J., Haynes M.A., Blacklow R.S., et al. Bladder cancer: Race differences in extent of disease at diagnosis. Cancer. 2000;89:1349–1358. doi: 10.1002/1097-0142(20000915)89:6<1349::AID-CNCR20>3.0.CO;2-D. - DOI - PubMed
    1. Di Meo N.A., Loizzo D., Pandolfo S.D., Autorino R., Ferro M., Porta C., Stella A., Bizzoca C., Vincenti L., Crocetto F., et al. Metabolomic Approaches for Detection and Identification of Biomarkers and Altered Pathways in Bladder Cancer. Int. J. Mol. Sci. 2022;23:4173. doi: 10.3390/ijms23084173. - DOI - PMC - PubMed
    1. Saginala K., Barsouk A., Aluru J.S., Rawla P., Padala S.A., Barsouk A. Epidemiology of Bladder Cancer. Med. Sci. 2020;8:15. doi: 10.3390/medsci8010015. - DOI - PMC - PubMed