Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 21;10(7):1351.
doi: 10.3390/healthcare10071351.

Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

Julien Ancel  1   2 , Claire Launois  1   2 , Jeanne-Marie Perotin  1   2 , Bruno Ravoninjatovo  1 , Pauline Mulette  1 , Jean Hagenburg  1 , Julie Malet  1 , Muriel Griffon  1 , Sophie Carré  1 , François Lebargy  1   3 , Gaëtan Deslée  1   2 , Sandra Dury  1   3
Affiliations

Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

Julien Ancel et al. Healthcare (Basel). .

Abstract

Background: Cystic Fibrosis (CF) adult patients experience daily physical symptoms and disabilities that may impact their quality of life and mental health.

Methods: This prospective study aimed to evaluate the relative contribution of the familial, occupational, and social environment, besides that of the main physical and mental health factors, to the quality of life of CF adult patients using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) in a multivariate model.

Results: Fifty patients were analyzed (70% of men; median age of 25 years; median body mass index of 21 kg/m²; median FEV1 of 57%). Anxiety and depression scores were negatively associated with 9 of the 12 CFQ-R domains. When controlling for anxiety and depression, FEV1% and BMI were significant positive predictors of several domains of the CFQ-R. All the familial, occupational, and social components analyzed but one (professional training) were predictors of at least one domain of the CFQ-R.

Conclusion: Anxiety and depression explained a greater proportion of the variance than physical variables (age, sex, BMI, FEV1%, and exacerbation in the last year) in CF HRQoL. Many familial, occupational, and social components were also specifically and independently predictors of some HRQoL domains. Their screening might help identifying CF patients eligible for specific interventions, focusing on the impaired QoL dimensions.

Keywords: CFQ-R; anxiety; cystic fibrosis; depression; quality of life.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Elborn J.S. Cystic Fibrosis. Lancet. 2016;388:2519–2531. doi: 10.1016/S0140-6736(16)00576-6. - DOI - PubMed
    1. Granados A., Chan C.L., Ode K.L., Moheet A., Moran A., Holl R. Cystic Fibrosis Related Diabetes: Pathophysiology, Screening and Diagnosis. J. Cyst Fibros. 2019;18((Suppl. 2)):S3–S9. doi: 10.1016/j.jcf.2019.08.016. - DOI - PubMed
    1. Anabtawi A., Le T., Putman M., Tangpricha V., Bianchi M.L. Cystic Fibrosis Bone Disease: Pathophysiology, Assessment and Prognostic Implications. J Cyst. Fibros. 2019;18((Suppl. 2)):S48–S55. doi: 10.1016/j.jcf.2019.08.018. - DOI - PubMed
    1. Hughan K.S., Daley T., Rayas M.S., Kelly A., Roe A. Female Reproductive Health in Cystic Fibrosis. J. Cyst. Fibros. 2019;18((Suppl. S2)):S95–S104. doi: 10.1016/j.jcf.2019.08.024. - DOI - PubMed
    1. Guta M.T., Tekalign T., Awoke N., Fite R.O., Dendir G., Lenjebo T.L. Global Burden of Anxiety and Depression among Cystic Fibrosis Patient: Systematic Review and Meta-Analysis. Int. J. Chronic Dis. 2021;2021:6708865. doi: 10.1155/2021/6708865. - DOI - PMC - PubMed

LinkOut - more resources