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Review
. 2022 Jun 27;13(7):1160.
doi: 10.3390/genes13071160.

Circulating microRNAs as the Potential Diagnostic and Prognostic Biomarkers for Nasopharyngeal Carcinoma

Thuy Ai Huyen Le  1 , Thuan Duc Lao  1
Affiliations
Review

Circulating microRNAs as the Potential Diagnostic and Prognostic Biomarkers for Nasopharyngeal Carcinoma

Thuy Ai Huyen Le et al. Genes (Basel). .

Abstract

microRNAs are endogenous non-coding miRNAs, 19-25 nucleotides in length, that can be detected in the extracellular environment in stable forms, named circulating miRNAs (CIR-miRNAs). Since the first discovery of CIR-miRNAs, a large number of studies have demonstrated that the abnormal changes in its expression could be used to significantly distinguish nasopharyngeal carcinoma (NPC) from healthy cells. We herein reviewed and highlighted recent advances in the study of CIR-miRNAs in NPC, which pointed out the main components serving as promising and effective biomarkers for NPC diagnosis and prognosis. Furthermore, brief descriptions of its origin and unique characteristics are provided.

Keywords: circulating microRNAs; extracellular miRNA; miRNA-based diagnosis; nasopharyngeal carcinoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The regulation of gene expression through the binding of miRNA.
Figure 2
Figure 2
MicroRNAs are exported from cells into circulation by many mechanisms.
See this image and copyright information in PMC

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