doi: 10.1016/0031-6989(87)90004-x.
WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage
- PMID: 3588650
- DOI: 10.1016/0031-6989(87)90004-x
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WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage
Pharmacol Res Commun.
1987 Feb.
Abstract
Single intravenous administration of platelet activating factor (PAF; 4 micrograms/kg) induced reproducible gastric damage in the conscious rat which was prevented by WEB 2086, a potent and specific PAF-antagonist. Intravenous and oral ED50s in protecting rats from gastric damage were 61 and 633 micrograms/kg, respectively. Because of the reported association between septic shock and gastrointestinal ulceration, the therapeutic potential of PAF-antagonists might be broader than previously thought.
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