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Review
. 2022 Jul 13;23(14):7732.
doi: 10.3390/ijms23147732.

Function and Application of Flavonoids in the Breast Cancer

Min Yeong Park  1 , Yoonjung Kim  2 , Sang Eun Ha  1   3 , Hun Hwan Kim  1 , Pritam Bhangwan Bhosale  1 , Abuyaseer Abusaliya  1 , Se Hyo Jeong  1 , Gon Sup Kim  1
Affiliations
Review

Function and Application of Flavonoids in the Breast Cancer

Min Yeong Park et al. Int J Mol Sci. .

Abstract

Breast cancer is one of the top causes of death, particularly among women, and it affects many women. Cancer can also be caused by various factors, including acquiring genetic alteration. Doctors use radiation to detect and treat breast cancer. As a result, breast cancer becomes radiation-resistant, necessitating a new strategy for its treatment. The approach discovered by the researchers is a flavonoid, which is being researched to see if it might help treat radiation-resistant breast cancer more safely than an approved medicine already being used in the field. As a result, this study focuses on the role of flavonoids in breast cancer suppression, breast cancer gene anomalies, and the resulting apoptotic mechanism.

Keywords: apoptosis; breast cancer; flavonoid.

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Conflict of interest statement

The authors clearly declare that they have no conflict of interest in this study.

Figures

Figure 1
Figure 1
Structure of flavonoid. They were drawn by ChemDraw Pro 8.0.
Figure 1
Figure 1
Structure of flavonoid. They were drawn by ChemDraw Pro 8.0.
Figure 2
Figure 2
There are two pathways of apoptosis. There are extrinsic and intrinsic pathways, and both induce apoptosis.
Figure 3
Figure 3
Between oncogenes and proteins involved in apoptosis. It was discovered that there is a link between chemicals that inhibit apoptosis and the consequences that cause it.
Figure 4
Figure 4
Biological processes involving P53.
Figure 5
Figure 5
Flavonoid-induced apoptosis of breast cancer cells.
See this image and copyright information in PMC

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