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. 2022 Jul 8;11(14):3981.
doi: 10.3390/jcm11143981.

Correlation Analysis between Intraocular Pressure and Extraocular Muscles Based on Orbital Magnetic Resonance T2 Mapping in Thyroid-Associated Ophthalmopathy Patients

Ban Luo  1 , Wei Wang  1 , Xinyu Li  1 , Hong Zhang  1 , Yaoli Zhang  1 , Weikun Hu  1   2
Affiliations

Correlation Analysis between Intraocular Pressure and Extraocular Muscles Based on Orbital Magnetic Resonance T2 Mapping in Thyroid-Associated Ophthalmopathy Patients

Ban Luo et al. J Clin Med. .

Abstract

Background: The correlation between intraocular pressure (IOP) and the magnetic resonance imaging (MRI) parameters in thyroid-associated ophthalmopathy (TAO) patients was explored.

Methods: This study included 82 eyes in 41 TAO patients who had a large difference in the IOP between each eye. We measured the T2 relaxation time (T2RT) of the extraocular muscles (EOMs), the orbital fat, and the area of the EOMs.

Results: There was a positive correlation between IOP and exophthalmos, the clinical activity score (CAS), the T2RT (of the medial rectus (MR)), the area of the MR, inferior rectus (IR) and lateral rectus, and the mean area. We established a regression model with IOP as the dependent variable, and the area of the IR was statistically significant.

Conclusions: High IOP in TAO patients was positively correlated with the degree of exophthalmos and EOM inflammation (especially the inferior rectus). The state of the EOMs in an orbital MRI may partially explain high IOP and provide the necessary clinical information for subsequent high IOP treatment.

Keywords: T2 relaxation time; extraocular muscle; intraocular pressure; magnetic resonance imaging; thyroid-associated ophthalmopathy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Measurement of Orbital MRI-T2 Mapping Parameters. (a) Orbital coronal pseudo-color map, representing the T2RT value of the ROI in each EOM; (b) orbital coronal view, indicating the largest cross-sectional area of the EOM. T2RT, T2 relaxation time; ROI, region of interest; EOM, extraocular muscles.
Figure 2
Figure 2
Wilcoxon signed-rank test charts show the differences of the CAS score (a), the overall orbital T2 relaxation time—T2RT (Total) (b), the medial rectus muscle T2 relaxation time—T2RT(MR) (c), exophthalmos (d), the average extraocular muscle cross-sectional area—average area (e), the inferior rectus cross-sectional area-area (IR) (f), the medial rectus cross-sectional area—area (MR) (g), and the lateral rectus cross-sectional area—area(LR) (h) between the HIOP and LIOP groups. CAS, clinical activity score; T2RT, T2 relaxation time; MR, medial rectus; IR, inferior rectus; LR, lateral rectus; HIOP, high intraocular pressure; LIOP, low intraocular pressure; NS, not statistically different; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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