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Review
. 2022 Jul 20;14(14):2970.
doi: 10.3390/nu14142970.

Gut Microbiota in Psoriasis

Mihaela Cristina Buhaș  1 , Laura Ioana Gavrilaș  2 , Rareș Candrea  3 , Adrian Cătinean  4 , Andrei Mocan  5 , Doina Miere  2 , Alexandru Tătaru  1
Affiliations
Review

Gut Microbiota in Psoriasis

Mihaela Cristina Buhaș et al. Nutrients. .

Abstract

Psoriasis is a chronic inflammatory skin disease with autoimmune pathogenic characteristics and is caused by chronic inflammation, which results in uncontrolled keratinocyte growth and defective differentiation. The link between the gut microbiota and immune system regulation opened a novel angle to understand the pathogenesis of many chronic multifactorial diseases, including psoriasis. Current evidence suggests that modulation of the gut microbiota, both through dietary approaches and through supplementation with probiotics and prebiotics, could represent a novel therapeutic approach. The present work aims to highlight the latest scientific evidence regarding the microbiome alterations of psoriatic patients, as well as state of the art insights in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis.

Keywords: dietary approaches; microbiota; prebiotics; probiotics; psoriasis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Factors associated with gut microbiota composition.
Figure 2
Figure 2
The role of gut dysbiosis in the pathogenesis of psoriasis. The green arrow represents the low diversity of potentially beneficial bacteria in the gut microbiota of psoriasis patients. The red arrow represents the high diversity of potentially harmful bacteria in the gut microbiota of psoriasis patients.
See this image and copyright information in PMC

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