Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 26;11(7):726.
doi: 10.3390/pathogens11070726.

Prevalence of Transfusion-Transmitted Infections (HCV, HIV, Syphilis and Malaria) in Blood Donors: A Large-Scale Cross-Sectional Study

Talal Alharazi  1   2   3 , Tawfique K Alzubiery  4 , Jerold C Alcantara  1   3 , Husam Qanash  1   3 , Abdulrahman S Bazaid  1   3 , Malik A Altayar  5 , Abdu Aldarhami  6
Affiliations

Prevalence of Transfusion-Transmitted Infections (HCV, HIV, Syphilis and Malaria) in Blood Donors: A Large-Scale Cross-Sectional Study

Talal Alharazi et al. Pathogens. .

Abstract

Blood plays a major role in transmitting infectious diseases such as hepatitis C virus (HCV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), syphilis, malaria, and many others. Thus, this study sought to evaluate the distribution of HCV, HIV, syphilis, and malaria among blood donors in Yemen. This is a cross-sectional study, conducted on blood donors at the national center in Yemen. Blood donors' specimens were serologically tested for the presence of anti-HCV and anti-HIV antibodies, as well as anti-Treponema pallidum, anti-Plasmodium falciparum, and anti-Plasmodium vivax. A total of 16,367 donors were included in this study. Based on the donor's occupation, the study showed that the relative seroprevalence of anti-HCV Ab among the donors was statistically significant, and relatively high prevalence was found among military donors (2.8%). Positive HIV antibody tests were only reported in 33 male donors (0.2%), who were mostly manual workers. A remarkably high prevalence of anti-Treponema pallidum was observed among manual workers (3.1%). There was a statistically significant difference in the distribution of anti-malaria Ab based on residency and age groups. This study revealed that the prevalence of HCV, HIV, syphilis, and malaria among donors was 2.0%, 0.2%, 2.4%, and 0.7%, respectively. Further genotyping studies are necessary to provide a complete picture of the prevalence of transfusion-transmitted infections (TTIs).

Keywords: HCV; HIV; blood donors; malaria; syphilis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Mohammed Y., Bekele A. Seroprevalence of transfusion transmitted infection among blood donors at Jijiga blood bank, Eastern Ethiopia: Retrospective 4 years study. BMC Res. Notes. 2016;9:129. doi: 10.1186/s13104-016-1925-6. - DOI - PMC - PubMed
    1. World Health Organization . Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation. World Health Organization; Geneva, Switzerland: 2012. - PubMed
    1. Noubiap J.J., Joko W.Y., Nansseu J.R., Tene U.G., Siaka C. Sero-epidemiology of human immunodeficiency virus, hepatitis B and C viruses, and syphilis infections among first-time blood donors in Edéa, Cameroon. Int. J. Infect. Dis. 2013;17:e832–e837. doi: 10.1016/j.ijid.2012.12.007. - DOI - PubMed
    1. World Health Organization . Blood Safety and Availability. World Health Organization; Geneva, Switzerland: 2018. WHO Fact Sheet No. 279.
    1. Kasraian L., Hosseini S., Marzijarani M.S., Ebrahimi A., Ashkani-Esfahani S. The Prevalence of Hepatitis C Infection in Blood Donors: A Meta-Analysis and Systematic Review. Iran. Red Crescent Med. J. 2020;22:e94998. doi: 10.5812/ircmj.94998. - DOI

LinkOut - more resources