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Review
. 2022 Jul 17;15(7):879.
doi: 10.3390/ph15070879.

Bone Tissue Engineering in the Treatment of Bone Defects

Nannan Xue  1   2 , Xiaofeng Ding  1 , Rizhong Huang  1 , Ruihan Jiang  1 , Heyan Huang  1 , Xin Pan  2 , Wen Min  1 , Jun Chen  1 , Jin-Ao Duan  2 , Pei Liu  2 , Yiwei Wang  1   2   3
Affiliations
Review

Bone Tissue Engineering in the Treatment of Bone Defects

Nannan Xue et al. Pharmaceuticals (Basel). .

Abstract

Bones play an important role in maintaining exercise and protecting organs. Bone defect, as a common orthopedic disease in clinics, can cause tremendous damage with long treatment cycles. Therefore, the treatment of bone defect remains as one of the main challenges in clinical practice. Today, with increased incidence of bone disease in the aging population, demand for bone repair material is high. At present, the method of clinical treatment for bone defects including non-invasive therapy and invasive therapy. Surgical treatment is the most effective way to treat bone defects, such as using bone grafts, Masquelet technique, Ilizarov technique etc. In recent years, the rapid development of tissue engineering technology provides a new treatment strategy for bone repair. This review paper introduces the current situation and challenges of clinical treatment of bone defect repair in detail. The advantages and disadvantages of bone tissue engineering scaffolds are comprehensively discussed from the aspect of material, preparation technology, and function of bone tissue engineering scaffolds. This paper also summarizes the 3D printing technology based on computer technology, aiming at designing personalized artificial scaffolds that can accurately fit bone defects.

Keywords: 3D printing; biomaterials; bone defect; scaffolds; tissue engineering; tissue regeneration.

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Conflict of interest statement

There are no conflict of interest to declare.

Figures

Figure 1
Figure 1
Surgical treatment for repairing bone defects. Bone transplantation, prosthetic surgery, reoperation, and fracture fixation are listed as the top four surgical treatments.
Figure 2
Figure 2
Different exogenous stimulation promotes the recovery of bone defects.
See this image and copyright information in PMC

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