3D and 4D Printing in the Fight against Breast Cancer

Abstract

Breast cancer is the second most common cancer worldwide, characterized by a high incidence and mortality rate. Despite the advances achieved in cancer management, improvements in the quality of life of breast cancer survivors are urgent. Moreover, considering the heterogeneity that characterizes tumors and patients, focusing on individuality is fundamental. In this context, 3D printing (3DP) and 4D printing (4DP) techniques allow for a patient-centered approach. At present, 3DP applications against breast cancer are focused on three main aspects: treatment, tissue regeneration, and recovery of the physical appearance. Scaffolds, drug-loaded implants, and prosthetics have been successfully manufactured; however, some challenges must be overcome to shift to clinical practice. The introduction of the fourth dimension has led to an increase in the degree of complexity and customization possibilities. However, 4DP is still in the early stages; thus, research is needed to prove its feasibility in healthcare applications. This review article provides an overview of current approaches for breast cancer management, including standard treatments and breast reconstruction strategies. The benefits and limitations of 3DP and 4DP technologies are discussed, as well as their application in the fight against breast cancer. Future perspectives and challenges are outlined to encourage and promote AM technologies in real-world practice.

Keywords: 3D printing; 4D printing; additive manufacturing; breast cancer; drug delivery.

Figure 1

Schematic illustration of breast cancer progression.

Figure 2

Schematic representation of 3DP techniques, reproduced with permission from Elsevier, license number 5334150461456 [38].

Figure 3

Shape memory effect of alloys, reproduced with permission from Elsevier, license number 5334150011086 [62].

Figure 4

Shape memory effect of polymersreproduced with permission from Elsevier, license number 5334150884441 [68].

Figure 5

Patient-specific surgical guides [80,81].

Figure 6

Showing (a) structure of the scaffold; (b–f) implantation of the scaffold and fat injection process; and (g) scaffold’s properties [94].

Figure 7

Schematic illustration of NIR-triggered drug release.