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Review
. 2022 Jun 30;11(3):23.
doi: 10.3390/biotech11030023.

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic

Ana María Sánchez de la Nava  1   2 , Lidia Gómez-Cid  1   2   3 , Gonzalo Ricardo Ríos-Muñoz  1   2   3 , María Eugenia Fernández-Santos  1   2 , Ana I Fernández  1   2 , Ángel Arenal  1   2   4 , Ricardo Sanz-Ruiz  1   2 , Lilian Grigorian-Shamagian  1   2 , Felipe Atienza  1   2   4 , Francisco Fernández-Avilés  1   2   4
Affiliations
Review

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic

Ana María Sánchez de la Nava et al. BioTech (Basel). .

Abstract

Translational science has been introduced as the nexus among the scientific and the clinical field, which allows researchers to provide and demonstrate that the evidence-based research can connect the gaps present between basic and clinical levels. This type of research has played a major role in the field of cardiovascular diseases, where the main objective has been to identify and transfer potential treatments identified at preclinical stages into clinical practice. This transfer has been enhanced by the intromission of digital health solutions into both basic research and clinical scenarios. This review aimed to identify and summarize the most important translational advances in the last years in the cardiovascular field together with the potential challenges that still remain in basic research, clinical scenarios, and regulatory agencies.

Keywords: cardiovascular diseases; digital health; translational medicine.

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Conflict of interest statement

Fernández-Avilés and Atienza have equity from Corify Care SL. Atienza and Arenal served on the advisory board of Medtronic. None of the other authors has any conflict of interest, financial or otherwise, to disclose.

Figures

Figure 1
Figure 1
Translational approach from basic research to bedside and clinical practice, describing the three different translational research types.
Figure 2
Figure 2
Preclinical and clinical trial development diagram including the type of research used for the characterization of any treatment (basic research, animal models) and the estimated number of participants for each phase in clinical trials.
Figure 3
Figure 3
Current challenges and opportunities in the field of translational research.
See this image and copyright information in PMC

References

    1. Saner H., Van Der Velde E. eHealth in Cardiovascular Medicine: A Clinical Update. Eur. J. Prev. Cardiol. 2016;23:5–12. doi: 10.1177/2047487316670256. - DOI - PubMed
    1. Luchini C., Pea A., Scarpa A. Artificial Intelligence in Oncology: Current Applications and Future Perspectives. Br. J. Cancer. 2021;126:4–9. doi: 10.1038/s41416-021-01633-1. - DOI - PMC - PubMed
    1. Pedersen M., Verspoor K., Jenkinson M., Law M., Abbott D.F., Jackson G.D. Artificial Intelligence for Clinical Decision Support in Neurology. Brain Commun. 2020;2:fcaa096. doi: 10.1093/braincomms/fcaa096. - DOI - PMC - PubMed
    1. De Marvao A., Dawes T.J.W., Howard J.P., O’Regan D.P. Artificial Intelligence and the Cardiologist: What You Need to Know for 2020. Heart. 2020;106:399–400. doi: 10.1136/heartjnl-2019-316033. - DOI - PMC - PubMed
    1. Visseren F.L.J., MacH F., Smulders Y.M., Carballo D., Koskinas K.C., Bäck M., Benetos A., Biffi A., Boavida J.M., Capodanno D., et al. 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice. Eur. Heart J. 2021;42:3227–3337. doi: 10.1093/EURHEARTJ/EHAB484. - DOI - PubMed

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