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. 2022 Aug;18(26):2919-2931.
doi: 10.2217/fon-2022-0321. Epub 2022 Jul 27.

Plasma exosomal miR-1260a, miR-7977 and miR-192-5p as diagnostic biomarkers in epithelial ovarian cancer

Liang Chen  1   2 , Kangyu Wang  3 , Lei Li  4 , Baibing Zheng  3 , Qianru Zhang  3 , Fang Zhang  5 , Jinlong Chen  2 , Shiwen Wang  3
Affiliations

Plasma exosomal miR-1260a, miR-7977 and miR-192-5p as diagnostic biomarkers in epithelial ovarian cancer

Liang Chen et al. Future Oncol. 2022 Aug.

Abstract

Aim: The study aimed to clarify the diagnostic value of exosomal miRNAs in epithelial ovarian cancer (EOC). Methods: Plasma exosomes were isolated from peripheral blood of EOC patients and healthy donors by ultracentrifugation and verified by transmission electron microscopy, qNano and western blot. The expression of exosomal miRNAs was detected by quantitative PCR, and the diagnostic efficiency of exosomal miRNAs was evaluated by receiver operating characteristic analysis. Results: Exosomal miR-1260a, miR-7977 and miR-192-5p were significantly decreased in EOC as compared with healthy controls. The area under the curve of the combination of three exosomal miRNAs was 0.8337. Moreover, the level of exosomal miR-7977 was related to the neutrophil-lymphocyte ratio, which decreased in EOC patients with a high neutrophil-lymphocyte ratio. Conclusion: Exosomal miR-1260a, miR-7977 and miR-192-5p act as potentially EOC diagnostic and prognostic biomarkers.

Keywords: biomarkers; diagnosis; gynecologic/ovarian; prognosis.

Plain language summary

This study aimed to identify some miRNAs that can act as predictive and diagnostic markers of ovarian cancer (OC). To do this, miRNAs were isolated from blood samples of OC patients and healthy donors. The level of miRNAs was tested, and the diagnostic value was analyzed using software. Three miRNAs were identified that could be predictive of OC and OC outcome.

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