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. 2022 Jul 19;10(4):86.
doi: 10.3390/pharmacy10040086.

A Guide to a Pharmacist-Led Pharmacogenetic Testing and Counselling Service in an Interprofessional Healthcare Setting

Céline K Stäuble  1   2   3 , Chiara Jeiziner  1 , Anna Bollinger  1 , Florine M Wiss  1   2 , Martin Hatzinger  4 , Kurt E Hersberger  1 , Thomas Ihde  5 , Markus L Lampert  1   2 , Thorsten Mikoteit  4 , Henriette E Meyer Zu Schwabedissen  3 , Samuel S Allemann  1
Affiliations

A Guide to a Pharmacist-Led Pharmacogenetic Testing and Counselling Service in an Interprofessional Healthcare Setting

Céline K Stäuble et al. Pharmacy (Basel). .

Abstract

Genetic predisposition is one factor influencing interindividual drug response. Pharmacogenetic information can be used to guide the selection and dosing of certain drugs. However, the implementation of pharmacogenetics (PGx) in clinical practice remains challenging. Defining a formal structure, as well as concrete procedures and clearly defined responsibilities, may facilitate and increase the use of PGx in clinical practice. Over 140 patient cases from an observational study in Switzerland formed the basis for the design and refinement of a pharmacist-led pharmacogenetics testing and counselling service (PGx service) in an interprofessional setting. Herein, we defined a six-step approach, including: (1) patient referral; (2) pre-test-counselling; (3) PGx testing; (4) medication review; (5) counselling; (6) follow-up. The six-step approach supports the importance of an interprofessional collaboration and the role of pharmacists in PGx testing and counselling across healthcare settings.

Keywords: clinical pharmacy; community pharmacy; hospital pharmacy; medication review; personalized medicine; pharmaceutical care; pharmacogenomics; pharmacy service; primary care; secondary care.

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Conflict of interest statement

The authors declare no conflict of interest, no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. No writing assistance was involved in the preparation of the manuscript.

Figures

Figure 1
Figure 1
Study procedure of the observational case series study. ADR: adverse drug reaction; TF: treatment failure; PGx: pharmacogenetic.
Figure 2
Figure 2
Overview of the pharmacist-led PGx service in an interprofessional setting.
See this image and copyright information in PMC

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