Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 24;14(15):2993.
doi: 10.3390/polym14152993.

Preparation and In Vitro Evaluation of Controlled-Release Matrices of Losartan Potassium Using Ethocel Grade 10 and Carbopol 934P NF as Rate-Controlling Polymers

Kamran Ahmad Khan  1 , Claudia Zizzadoro  2 , Alessandro Di Cerbo  3 , Nicola Pugliese  2 , Gul Majid Khan  4 , Shakira Ghazanfar  5 , Eman M Almusalami  6 , Muhammad Muzammal  7 , Khaled J Alsalman  8 , Arshad Farid  7
Affiliations

Preparation and In Vitro Evaluation of Controlled-Release Matrices of Losartan Potassium Using Ethocel Grade 10 and Carbopol 934P NF as Rate-Controlling Polymers

Kamran Ahmad Khan et al. Polymers (Basel). .

Abstract

Controlled-release formulations are essential for those drugs that require fine tuning of their activity to increase the ratio between therapeutic vs. adverse effects. Losartan potassium is among those drugs whose adverse effects may somehow impair its purported benefits. Previous investigations have been carried out to ascertain the suitability of several polymers for being associated with losartan. This study is focused on the effects of Ethocel grade 10 and Carbopol 934P NF on losartan release. Flow and physical properties were assessed according to the protocols standardized by the pharmacopeia (USP-NF 29), and the drug release in phosphate buffer (pH = 6.8) was measured for 24 h. Data evidenced good to excellent flow and physical properties according to the drug/polymer ratio and the addition of co-excipients. The release rate in 24 h was found to be 63-69% to 79-82% without or with the addition of co-excipients, respectively, following zero-order kinetics. The results also suggest a significant difference with the release profile of a traditional release losartan formulation. The results suggest the suitability of Ethocel grade 10 and Carbopol 934P NF as components of a controlled-release losartan formulation.

Keywords: Carbopol 934P NF; Ethocel grade 10; dissolution; formulation; kinetic models.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Drug release from polymeric matrices. The points in the curves indicate the mean value of three repetitions.
Figure 2
Figure 2
Drug release from polymeric matrices when co-excipients were added. The points in the curves indicate the mean value of three repetitions.
See this image and copyright information in PMC

References

    1. Alqahtani M.S., Kazi M., Alsenaidy M.A., Ahmad M.Z. Advances in Oral Drug Delivery. Front. Pharmacol. 2021;12:618411. doi: 10.3389/fphar.2021.618411. - DOI - PMC - PubMed
    1. Modi S.A., Gaikwad P.D., Bankar V.H., Pawar S.P. Sustained release drug delivery system: A review. Int. J. Pharm. Res. Dev. 2011;2:147–160.
    1. Pahade A., Pahade A., Jadhav V.M., Kadam V.J. Formulation and development of sustained release matrix tablet of nicorandil. Int. J. Pharm. Sci. Rev. Res. 2010;4:107–111.
    1. Mastropietro D.J., Park K., Omidian H. Polymers in Oral Drug Delivery. In: Ducheyne P., Grainger D.W., Healy K.E., Hutmacher D.W., Kirkpatrick C.J., editors. Comprehensive Biomaterials. 2nd ed. Volume 4. Elsevier; Amsterdam, The Netherlands: 2017. pp. 430–444. Biocompatibility, Surface Engineering and Delivery of Drugs, Genes and Other Molecules.
    1. Israr M., Pugliese N., Farid A., Ghazanfar S., Di Cerbo A., Muzammal M., Alamri A.S., Basheeruddin Asdaq S.M., Ahmad A., Khan K.A. Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin. Molecules. 2022;27:3242. doi: 10.3390/molecules27103242. - DOI - PMC - PubMed

LinkOut - more resources