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Review
. 2022 Sep 1;31(5):435-441.
doi: 10.1097/MNH.0000000000000824. Epub 2022 Jul 15.

Pruritus in chronic kidney disease

Nupur N Uppal  1 , Antonio Corona, Steven Fishbane
Affiliations
Review

Pruritus in chronic kidney disease

Nupur N Uppal et al. Curr Opin Nephrol Hypertens. .

Abstract

Purpose of review: Among the many difficult symptoms that patients with kidney disease experience, pruritus is one of the most frequent and troubling. Because a substantial amount of new information has accumulated, we seek here to review the subject.

Recent findings: Pruritus is not only a common problematic symptom among patients with kidney disease, but its considerably more frequent than nephrologists recognize. The result for patients is not just uncomfortable itch but degraded quality of life as well. The pathogenesis is increasingly understood, but many aspects remain to be fully resolved. Importantly, research is progressing on treatment, leading to the first approved medication in the United States, difelikefalin, in August, 2021.

Summary: As nephrology is progressing to a greater focus on patient symptoms, recognition of the importance of pruritus has led to increased interest and improved diagnosis and treatment options.

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References

    1. Verduzco HA, Shirazian S. CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management. Kidney Int Rep 2020; 5:1387–1402.
    1. Sukul N, Karaboyas A, Csomor PA, et al. Self-reported pruritus and clinical, dialysis-related, and patient-reported outcomes in hemodialysis patients. Kidney Med 2020; 3:42–53.e1.
    1. Hu X, Sang Y, Yang M, et al. Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients: a meta-analysis of cross-sectional studies. Medicine (Baltimore) 2018; 97:e10633.
    1. Rayner HC, Larkina M, Wang M, et al. International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis. Clin J Am Soc Nephrol 2017; 12:2000–2007.
    1. Schricker S, Weisshaar E, Kupfer J, Mettang T. Prevalence of pruritus in a single cohort of long-term kidney transplant recipients. Acta Derm Venereol 2020; 100:adv00066.