Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Dora Stölzl¹, Nicole Sander¹, Annice Heratizadeh², Eva Haufe³, Inken Harder¹, Susanne Abraham⁴, Luise Heinrich³, Andreas Kleinheinz⁵, Andreas Wollenberg⁶, Elke Weisshaar⁷, Knut Schäkel⁸, Konstantin Ertner⁹, Franca Wiemers¹⁰, Julia Wildberger¹¹, Margitta Worm¹², Ralph von Kiedrowski¹³, Isaak Effendy¹⁴, Andrea Asmussen¹⁵, Matthias Augustin¹⁶, Mario Pawlak¹⁷, Michael Sticherling¹⁸, Alexander Zink¹⁹, Melanie Hilgers²⁰, Christiane Handrick²¹, Sven Quist²², Beate Schwarz²³, Petra Staubach-Renz²⁴, Magnus Bell²⁵, Sun-Hei Hong-Weldemann²⁶, Bernhard Homey²⁷, Jens-Joachim Brücher²⁸, Jochen Schmitt³, Thomas Werfel², Stephan Weidinger¹; TREATgermany study group

Affiliations

¹ Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
² Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
³ Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
⁴ Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
⁵ Clinics for Dermatology, Elbe Klinikum Buxtehude, Germany.
⁶ Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich, Germany.
⁷ Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.
⁸ Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.
⁹ Practice Dr. med. Konstantin Ertner, Nürnberg, Germany.
¹⁰ Practice Dr. med. Franca Wiemers, Leipzig, Germany.
¹¹ Practice Dr. med. Julia Wildberger, Hautmedizin, Bad Soden, Germany.
¹² Clinics for Dermatology, Venerology and Allergy, Charité Berlin, Germany.
¹³ CMSS - Company for Medical Study and Service, Selters, Westerwald, Germany.
¹⁴ Department of Dermatology, Hospital Rosenhoehe, Bielefeld, Germany.
¹⁵ Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.
¹⁶ Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg-Eppendorf, Germany.
¹⁷ Practice Dr. med. Anika Hünermund and Mario Pawlak, Heilbad Heiligenstadt, Germany.
¹⁸ Department of Dermatology, University Hospital, Friedrich-Alexander-University Erlangen-Nuernberg, Germany.
¹⁹ Department of Dermatology and Allergy, School of Medicine, Technical University of Munich and Clinical Unit Allergology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Germany.
²⁰ Clinics for Dermatology and Allergy, University Hospital Aachen, Germany.
²¹ Practice Dr. med. Christiane Handrick, Berlin, Germany.
²² Dermatology Clinic, Helix Medical Excellence Center Mainz, Germany.
²³ Practice Dr. med. Beate Schwarz, Langenau, Germany.
²⁴ Department of Dermatology and Allergy, University Medical Center Mainz, Germany.
²⁵ Practice Dr. med. Magnus Bell, Thomas Kaiser, Andernach, Germany.
²⁶ Practice Dr. med. Sun-Hei Hong-Weldemann, Freiburg, Germany.
²⁷ Department of Dermatology, Heinrich-Heine-University Duesseldorf, Germany.
²⁸ Hautambulatorium Magdeburg, Germany.

PMID: 35895855
DOI: 10.1111/bjd.21794

Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Dora Stölzl et al. Br J Dermatol. 2022 Dec.

. 2022 Dec;187(6):1022-1024.

doi: 10.1111/bjd.21794. Epub 2022 Sep 6.

Authors

Affiliations

¹ Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
² Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
³ Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
⁴ Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
⁵ Clinics for Dermatology, Elbe Klinikum Buxtehude, Germany.
⁶ Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich, Germany.
⁷ Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.
⁸ Department of Dermatology, Ruprecht-Karls University Heidelberg, Germany.
⁹ Practice Dr. med. Konstantin Ertner, Nürnberg, Germany.
¹⁰ Practice Dr. med. Franca Wiemers, Leipzig, Germany.
¹¹ Practice Dr. med. Julia Wildberger, Hautmedizin, Bad Soden, Germany.
¹² Clinics for Dermatology, Venerology and Allergy, Charité Berlin, Germany.
¹³ CMSS - Company for Medical Study and Service, Selters, Westerwald, Germany.
¹⁴ Department of Dermatology, Hospital Rosenhoehe, Bielefeld, Germany.
¹⁵ Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.
¹⁶ Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg-Eppendorf, Germany.
¹⁷ Practice Dr. med. Anika Hünermund and Mario Pawlak, Heilbad Heiligenstadt, Germany.
¹⁸ Department of Dermatology, University Hospital, Friedrich-Alexander-University Erlangen-Nuernberg, Germany.
¹⁹ Department of Dermatology and Allergy, School of Medicine, Technical University of Munich and Clinical Unit Allergology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Germany.
²⁰ Clinics for Dermatology and Allergy, University Hospital Aachen, Germany.
²¹ Practice Dr. med. Christiane Handrick, Berlin, Germany.
²² Dermatology Clinic, Helix Medical Excellence Center Mainz, Germany.
²³ Practice Dr. med. Beate Schwarz, Langenau, Germany.
²⁴ Department of Dermatology and Allergy, University Medical Center Mainz, Germany.
²⁵ Practice Dr. med. Magnus Bell, Thomas Kaiser, Andernach, Germany.
²⁶ Practice Dr. med. Sun-Hei Hong-Weldemann, Freiburg, Germany.
²⁷ Department of Dermatology, Heinrich-Heine-University Duesseldorf, Germany.
²⁸ Hautambulatorium Magdeburg, Germany.

PMID: 35895855
DOI: 10.1111/bjd.21794

Abstract

This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.

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References

1. Simpson EL, Bieber T, Guttman-Yassky E et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med 2016; 375:2335-48.
1. Ratchataswan T, Banzon TM, Thyssen JP et al. Biologics for treatment of atopic dermatitis: current status and future prospect. J Allergy Clin Immunol Pract 2021; 9:1053-65.
1. Stölzl D, Weidinger S, Drerup K. A new era has begun: treatment of atopic dermatitis with biologics. Allergol Select 2021; 5:265-73.
1. Drucker AM, Morra DE, Prieto-Merino D et al. Systemic immunomodulatory treatments for atopic dermatitis: update of a living systematic review and network meta-analysis. JAMA Dermatol 2022; 158:523-32.
1. Schmitt J, Abraham S, Trautmann F et al. Usage and effectiveness of systemic treatments in adults with severe atopic eczema: first results of the German Atopic Eczema Registry TREATgermany. J Dtsch Dermatol Ges 2017; 15:49-59.

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TREATgermany is an academia-led, investigator-initiated clinical registry that is ﬁnancially supported by AbbVie GmbH & Co KG, Galderma SA, LEO Pharma GmbH, Lilly Deutschland GmbH, Pfizer Inc. and Sanoﬁ Deutschland GmbH.

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Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Affiliations

Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources