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Comment
. 2023 Jan;72(1):1-2.
doi: 10.1136/gutjnl-2022-328068. Epub 2022 Jul 27.

No H. pylori, no adenocarcinoma for patients with autoimmune gastritis

James Goldenring  1   2
Affiliations
Comment

No H. pylori, no adenocarcinoma for patients with autoimmune gastritis

James Goldenring. Gut. 2023 Jan.
No abstract available

Keywords: GASTRIC CANCER; GASTRIC METAPLASIA; HELICOBACTER PYLORI - GASTRITIS; NEUROENDOCRINE TUMORS.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1:
Figure 1:. Comparison of lineages changes in H. pylori-associated and autoimmune gastritis-associated atrophic gastritis.
Chronic H. pylori (Hp) infection induces parietal cell loss (atrophic gastritis) followed by induction of pyloric metaplasia. Continued inflammation induces incomplete intestinal metaplasia, which can then develop into gastric adenocarcinoma. In autoimmune gastritis patients, anti-parietal cell antibodies cause atrophic gastritis. Loss of parietal cells leads to subsequent induction of pyloric metaplasia which may progress to complete intestinal metaplasia. Additionally, the atrophic milieu in autoimmune gastritis patients can promote the evolution of ECL cell hyperplasia and eventually carcinoid tumors.
See this image and copyright information in PMC

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References

    1. El-Zimaity HMT, Ota H, Graham DY, et al. Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer 2002;94:1428–36. - PubMed
    1. Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology 1985;88:638–48. - PubMed
    1. Vannella L, Lahner E, Annibale B. Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal. World J Gastroenterol 2012;18:1279–85. - PMC - PubMed
    1. Song M, Camargo MC, Derkach A, et al. Associations between autoimmune conditions and gastric cancer risk among elderly adults in the United States. Am J Gastroenterol 2022;117:486–90. - PMC - PubMed
    1. Butt J, Lehtinen M, Öhman H, et al. Association of Helicobacter pylori and autoimmune gastritis with stomach cancer in a cohort of young Finnish women. Gastroenterology 2022;163:305–7. - PubMed

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