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. 2022 Sep;72(9):2011-2019.
doi: 10.1007/s12031-022-02050-6. Epub 2022 Jul 27.

Tumor Resident, B-Cell Receptor Chemical Characteristics Associated with Better Overall Survival for Neuroblastoma

Dorottya B Kacsoh  1 , Dhruv N Patel  2 , Monica Hsiang  2 , Etienne C Gozlan  2 , Andrea Chobrutskiy  3 , Boris I Chobrutskiy  4 , George Blanck  5   6
Affiliations

Tumor Resident, B-Cell Receptor Chemical Characteristics Associated with Better Overall Survival for Neuroblastoma

Dorottya B Kacsoh et al. J Mol Neurosci. 2022 Sep.

Abstract

Pediatric neuroblastoma (NBL) is one of the most common pediatric cancers, and it can often be aggressive. Genetic and demographic factors can correlate with the severity of NBL, but the variations in the B-cell receptors (BCRs) or immunoglobulin proteins present in the NBL tumors, and their relationships to survival, are not well understood. BCRs contain variations in their complementary determining region-3 (CDR3s) amino acid sequences, due to variable recombinations of the V- and J-gene segments. Accordingly, these variations in CDR3s may represent different antigen interactions and thereby different survival probabilities. Thus, we mined the TARGET project, NBL tumor RNAseq files for BCR recombination reads. Evaluations of the physicochemical properties of IGK, IGL, and IGH CDR3s from these tumors pointed to properties of IGK and IGL in particular as associated with survival distinctions, based on several independent bioinformatics approaches, including a novel homology grouping approach facilitated by a recently developed web tool, adaptivematch.com. In conclusion, tumor resident BCR chemical features are likely useful for better risk stratification and for guiding therapy, and the availability of a user-friendly web tool will likely facilitate using BCR chemical features to meet those goals.

Keywords: B-cell receptors; Homology grouping of CDR3s; Pediatric neuroblastoma; Physicochemical assessments of CDR3s; Survival probabilities.

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References

    1. Arturo JF, Chobrutskiy BI, Yeagley M, Patel DN, Falasiri S, Patel JS, Blanck G (2020) Electrostatic complementarity of B-cell receptor CDR3s and TP53-mutant amino acids in breast cancer is associated with increased disease-free survival rates. Cell Mol Immunol 17(7):776–778 - DOI
    1. Aygun N (2018) Biological and genetic features of neuroblastoma and their clinical importance. Curr Pediatr Rev 14(2):73–90 - DOI
    1. Bosse KR, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, Rathi KS, Kendsersky NM, Randall M, Donovan L, Morrissy S, Sussman RT, Zhelev DV, Feng Y, Wang Y, Hwang J, Lopez G, Harenza JL, Wei JS, Pawel B, Bhatti T, Santi M, Ganguly A, Khan J, Marra MA, Taylor MD, Dimitrov DS, Mackall CL, Maris JM (2017) Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma. Cancer Cell 32(3):295–309 (e212) - DOI
    1. Chobrutskiy A, Chobrutskiy BI, Zaman S, Hsiang M, Blanck G (2020a) Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer. Breast Cancer Res Treat
    1. Chobrutskiy A, Chobrutskiy BI, Zaman S, Hsiang M, Blanck G (2021a) Chemical features of blood-borne TRG CDR3s associated with an increased overall survival in breast cancer. Breast Cancer Res Treat 185(3):591–600 - DOI

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