Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 27;22(1):289.
doi: 10.1186/s12893-022-01718-5.

Hemangiopericytoma/solitary fibrous tumor of the cranial base: a case series and literature review

Zhouying Peng  1   2   3   4 , Yumin Wang  1   2   3   4 , Yaxuan Wang  1   2   3   4 , Qinxuan Li  1   2   3   4 , Yan Fang  1   2   3   4 , Ruohao Fan  1   2   3   4 , Hua Zhang  1   2   3   4 , Weihong Jiang  5   6   7   8
Affiliations
Review

Hemangiopericytoma/solitary fibrous tumor of the cranial base: a case series and literature review

Zhouying Peng et al. BMC Surg. .

Abstract

Background: Hemangiopericytomas (HPCs) are uncommon soft tissue tumors. HPCs that grow in the cranial base are rare. Therefore, skull-base surgeons tend to overlook this disease. This study aimed to increase the awareness of HPCs by summarizing case data from our institution and related publications. We also aimed to contribute to the number of reported cases for future systematic reviews of HPCs.

Methods: This study included all patients who underwent surgery for HPC/solitary fibrous tumor (SFT) between August 2015 and August 2019. All surgeries were performed at Xiangya Hospital Central South University. We analyzed clinical characteristics, surgical highlights, treatment modalities, and outcomes.

Results: We included six patients, aged 32-64 years. Lesions were located in the parapharyngeal space in three patients, pterygopalatine fossa in two, and saddle area in one. All patients underwent nasal endoscopic endonasal surgery. In five patients, tumors involved the internal carotid artery (ICA). The exposure and protection of the ICA during surgery are challenging but critical to complete tumor removal. The 3-year overall survival(OS) rate was 66.7%.

Conclusions: HPC/SFTs are rare tumors of the cranial base that are prone to recurrence. Cranial base HPC/SFTs are often closely associated with the ICA. To our knowledge, this case series reports the largest number of cases of HPCs associated with the ICA. We believe that there is a strong relationship between patient prognosis and whether the tumor encircles the ICA and whether the tumor is completely resected. To confirm this suggestion, more cases are needed for further analysis.

Keywords: Case series; Cranial base; Hemangiopericytoma; Solitary fibrous tumor; Survival.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Fig. 1
Fig. 1
Swimming-plot shows the treatment process for each patient
Fig. 2
Fig. 2
Patient #3’s pre- and postoperative imaging of ICA balloon embolization. a, b he preoperative imaging, yellow arrow indicates the pseudoaneurysm. c The post-operative imaging
Fig. 3
Fig. 3
Preoperative and postoperative MRI images of the cranial base. a Patient #1. b Patient #2. c Patient #4. d Patient #6
Fig. 4
Fig. 4
Exposure and protection of ICA in endoscopic endonasal surgery. a Reveal the contents of the PF. b, c Removal of the ET and preservation of the EVP. d–g Removal of lesions around ICA, free ICA. h Fill in autologous fat. i Reconstruction of cranial base with LNF. SS, sphenoid sinus; PS: pterygoid process; IA: infraorbital artery; MA: maxillary artery; PF: pterygopalatine fossa; ET: eustachian tube; EVP: evator veli palatine; IPS: inferior petrosal sinus; ICA: internal carotid artery; PD: petrous drum; LNF: lateral nasal flap
Fig. 5
Fig. 5
a Shows the summarization of clinical symptoms of patients with cranial base HPC/SFT from currently available publications. b Shows the HE staining picture of the typical HPCs’ patient
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring zimmermann’s pericytes. Ann Surg. 1942;116(1):26–33. doi: 10.1097/00000658-194207000-00004. - DOI - PMC - PubMed
    1. Kuo FY, Lin HC, Eng HL, Huang CC. Sinonasal hemangiopericytoma-like tumor with true pericytic myoid differentiation: a clinicopathologic and immunohistochemical study of five cases. Head Neck. 2005;27(2):124–129. doi: 10.1002/hed.20122. - DOI - PubMed
    1. Carew JF, Singh B, Kraus DH. Hemangiopericytoma of the head and neck. Laryngoscope. 1999;109(9):1409–1411. doi: 10.1097/00005537-199909000-00009. - DOI - PubMed
    1. Guthrie BL, Ebersold MJ, Scheithauer BW, Shaw EG. Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurgery. 1989;25(4):514–522. doi: 10.1227/00006123-198910000-00003. - DOI - PubMed
    1. Jääskeläinen J, Servo A, Haltia M, Wahlström T, Valtonen S. Intracranial hemangiopericytoma: radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol. 1985;23(3):227–236. doi: 10.1016/0090-3019(85)90087-4. - DOI - PubMed

MeSH terms

LinkOut - more resources