Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 11:13:882469.
doi: 10.3389/fendo.2022.882469. eCollection 2022.

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

Runzhu Liu  1   2 , Ruijia Dong  3 , Mengling Chang  1 , Xiao Liang  1 , Hayson Chenyu Wang  1
Affiliations
Review

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

Runzhu Liu et al. Front Endocrinol (Lausanne). .

Abstract

Diabetic wounds significantly affect the life quality of patients and may cause amputation and mortality if poorly managed. Recently, a wide range of cell-based methods has emerged as novel therapeutic methods in treating diabetic wounds. Adipose-derived stem cells (ASCs) are considered to have the potential for widespread clinical application of diabetic wounds treatment in the future. This review summarized the mechanisms of ASCs to promote diabetic wound healing, including the promotion of immunomodulation, neovascularization, and fibro synthesis. We also review the current progress and limitations of clinical studies using ASCs to intervene in diabetic wound healing. New methods of ASC delivery have been raised in recent years to provide a standardized and convenient use of ASCs.

Keywords: adipose-derived stem cells (ASC); cell therapy; diabetic ulcer; diabetic wound; diabetic wound healing.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The mechanism of diabetic wound healing and the role of adipose derived stem cells in diabetic wounds. (A) The change of endogenous ASCs in diabetic wounds. Red arrow represents diabetic environment influence on wound healing. (B) The influence of exogenous ASCs on diabetic wounds. Green arrow represents the mechanism of exogenous ASCs treatment on diabetic wound healing.
See this image and copyright information in PMC

References

    1. Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global Epidemiology of Diabetic Foot Ulceration: A Systematic Review and Meta-Analysis (†). Ann Med (2017) 49(2):106–16. doi: 10.1080/07853890.2016.1231932 - DOI - PubMed
    1. Zhao X, Guo J, Zhang F, Zhang J, Liu D, Hu W, et al. Therapeutic Application of Adipose-Derived Stromal Vascular Fraction in Diabetic Foot. Stem Cell Res Ther (2020) 11(1):394. doi: 10.1186/s13287-020-01825-1 - DOI - PMC - PubMed
    1. Reardon R, Simring D, Kim B, Mortensen J, Williams D, Leslie A. The Diabetic Foot Ulcer. Aust J Gen Pract (2020) 49(5):250–5. doi: 10.31128/AJGP-11-19-5161 - DOI - PubMed
    1. Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med (2017) 376(24):2367–75. doi: 10.1056/NEJMra1615439 - DOI - PubMed
    1. den Dekker A, Davis FM, Kunkel SL, Gallagher KA. Targeting Epigenetic Mechanisms in Diabetic Wound Healing. Transl Res (2019) 204:39–50. doi: 10.1016/j.trsl.2018.10.001 - DOI - PMC - PubMed

Publication types