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. 2022 Jul 11:13:905538.
doi: 10.3389/fendo.2022.905538. eCollection 2022.

Incidence, Morbidity and years Lived With Disability due to Type 2 Diabetes Mellitus in 204 Countries and Territories: Trends From 1990 to 2019

Rongrong Zhu  1 , Shan Zhou  2 , Liang Xia  3 , Xiaoming Bao  4
Affiliations

Incidence, Morbidity and years Lived With Disability due to Type 2 Diabetes Mellitus in 204 Countries and Territories: Trends From 1990 to 2019

Rongrong Zhu et al. Front Endocrinol (Lausanne). .

Abstract

Background: We aimed to examine the descriptive epidemiology and trends in the burden of type 2 diabetes mellitus (T2DM).

Methods: Data were extracted from the Global Burden of Disease 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the trends in incidence rate, mortality and disability-adjusted life-years (DALYs) associated with T2DM. Measures were stratified by sex, region, country, age and social development index (SDI) value.

Results: The global age-standardized incidence rate of T2DM increased from 1990 to 2019, with an EAPC of 1.25 (95% CI, 1.19 to 1.31). In 2019, the highest age-standardized incidence rate of T2DM was observed in high-SDI regions, and the largest increase in this rate from 1990 to 2019 was also in high-SDI regions (EAPC, 1.74;95% CI, 1.57 to 1.90). At the regional level, Central Asia (EAPC, 2.53;95% CI, 2.45 to 2.61) had the largest increase in the age-standardized incidence rate of T2DM from 1990 to 2019. At the national level, Luxembourg (EAPC, 4.51;95% CI, 4.37 to 4.65) and Uzbekistan (EAPC, 3.63; 95% CI, 3.44 to 3.82) had the largest increases in the age-standardized incidence rate of T2DM from 1990 to 2019. The global age-standardized death and DALY rates increased from 1990 to 2019, with EAPCs of 0.26 (95% CI, 0.16 to 0.37) and 0.81 (95% CI, 0.77 to 0.85), respectively. The age-standardized death and DALY rates showed the largest increases in Central Asia, South Asia and Southern Sub-Saharan Africa.

Conclusions: Globally, the age-standardized incidence, death and DALY rates increased from 1990 to 2019. Central Asia, South Asia and Southern Sub-Saharan Africa were found to have the greatest burden of T2DM. Future strategies should focus on these high-risk regions and other high-risk populations.

Keywords: disability-adjusted life-years; global burden of disease (GBD); incidence; mortality; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The EAPC of T2DM age-standardized rates from 1990 to 2019, by sex and region. (A) The EAPC of ASIR. (B) The EAPC of ASDR. (C) The EAPC of age-standardized DALY rate; EAPC, estimated annual percentage change.ASIR, age standardized incidence rate; ASDR, age standardized death rate; DALY, disability adjusted life-year.
Figure 2
Figure 2
The global EAPC of T2DM age-standardized rates from 1990 to 2019, by countries. (A) The EAPC of age-standardized incidence rate. (B) The EAPC of age-standardized death rate. (C) The EAPC of age-standardized DALY rate. EAPC, estimated annual percentage change; ASIR, age-standardized incidence rate; ASDR, age-standardized death rate; DALY, disability adjusted life-year.
See this image and copyright information in PMC

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