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Review
. 2022 Jul 11:13:924642.
doi: 10.3389/fimmu.2022.924642. eCollection 2022.

The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation

Chudai Zeng  1 , Jason Hu  2 , Fenghua Chen  1 , Tianxiang Huang  1 , Longbo Zhang  1   3
Affiliations
Review

The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation

Chudai Zeng et al. Front Immunol. .

Abstract

Epilepsy accounts for a significant proportion of the burden of neurological disorders. Neuroinflammation acting as the inflammatory response to epileptic seizures is characterized by aberrant regulation of inflammatory cells and molecules, and has been regarded as a key process in epilepsy where mTOR signaling serves as a pivotal modulator. Meanwhile, accumulating evidence has revealed that non-coding RNAs (ncRNAs) interfering with mTOR signaling are involved in neuroinflammation and therefore articipate in the development and progression of epilepsy. In this review, we highlight recent advances in the regulation of mTOR on neuroinflammatory cells and mediators, and feature the progresses of the interaction between ncRNAs and mTOR in epileptic neuroinflammation.

Keywords: epilepsy; mTOR; neural damage; neuroinflammation; non-coding RNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor WP declared a shared parent affiliation with the authors at the time of review.

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