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Review
. 2022 Jul 19:14:2215-2224.
doi: 10.2147/CMAR.S364761. eCollection 2022.

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Ling Lu #  1 , Qiaoyan Liang #  2 , Xinyi Zhang  3 , Yumeng Xu  3 , Dehua Meng  4 , Zhaofeng Liang  3
Affiliations
Review

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Ling Lu et al. Cancer Manag Res. .

Abstract

Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.

Keywords: autophagy; function; gastric cancer; noncoding RNA.

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Conflict of interest statement

All authors of this study declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of representative autophagy-related miRNAs in gastric cancer.
Figure 2
Figure 2
Role of representative autophagy-related lncRNAs in the progression, prognosis, and drug resistance of GC.
Figure 3
Figure 3
Role of representative autophagy-related circRNAs in the progression, prognosis, and drug resistance of GC.
See this image and copyright information in PMC

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