Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 19:14:2215-2224.
doi: 10.2147/CMAR.S364761. eCollection 2022.

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Ling Lu #  1 , Qiaoyan Liang #  2 , Xinyi Zhang  3 , Yumeng Xu  3 , Dehua Meng  4 , Zhaofeng Liang  3
Affiliations
Review

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Ling Lu et al. Cancer Manag Res. .

Abstract

Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.

Keywords: autophagy; function; gastric cancer; noncoding RNA.

PubMed Disclaimer

Conflict of interest statement

All authors of this study declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of representative autophagy-related miRNAs in gastric cancer.
Figure 2
Figure 2
Role of representative autophagy-related lncRNAs in the progression, prognosis, and drug resistance of GC.
Figure 3
Figure 3
Role of representative autophagy-related circRNAs in the progression, prognosis, and drug resistance of GC.
See this image and copyright information in PMC

References

    1. Arnold M, Abnet CC, Neale RE, et al. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology. 2020;159(1):335–349 e315. - PMC - PubMed
    1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. - PubMed
    1. Joshi SS, Badgwell BD. Current treatment and recent progress in gastric cancer. CA Cancer J Clin. 2021;71(3):264–279. - PMC - PubMed
    1. Saha S, Panigrahi DP, Patil S, Bhutia SK. Autophagy in health and disease: a comprehensive review. Biomed Pharmacother. 2018;104:485–495. - PubMed
    1. Denton D, Kumar S. Autophagy-dependent cell death. Cell Death Differ. 2019;26(4):605–616. - PMC - PubMed