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Review
. 2023 Jan;51(1):26-35.
doi: 10.1002/dc.25019. Epub 2022 Jul 28.

Overview and update on molecular testing in non-small cell lung carcinoma utilizing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples

María Jesús Fernández Aceñero  1 , Cristina Díaz Del Arco  1 , Carme Dinarés  2 , Tania Labiano  3 , Eva Tejerina  4 , Mª José Bernabé  5 , Elena Forcen  5 , Melchor Saiz-Pardo  1 , Pablo Pérez  1 , Maria D Lozano  3
Affiliations
Review

Overview and update on molecular testing in non-small cell lung carcinoma utilizing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples

María Jesús Fernández Aceñero et al. Diagn Cytopathol. 2023 Jan.

Abstract

Lung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of endobronchialultrasonographic bronchoscopy that allows a conservative staging of lung tumors, avoiding the need of mediastinoscopy for lymph node staging. Lung pathologists and cytopathologists are facing the challenge of giving the more comprehensive prognostic and predictive information with ever smaller tissue or cytological samples. The aim of this review is to summarize the molecular testing for non-small cell lung carcinoma and how pathologists can contribute to the patient's outcome with a conscious management of biological samples.

Keywords: endobronchial ultrasonographic broncoscopy; molecular pathology; non-small cell lung carcinoma; targeted therapies.

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References

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