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. 2023 May;306(5):1111-1130.
doi: 10.1002/ar.25044. Epub 2022 Jul 28.

Interleukin 15 in murine models of colitis

Alicia Molina Kautzman  1 , Jeanne Masunga Faida Mobulakani  1 , Gisela Marrero Cofino  2 , Akouavi Julite Irmine Quenum  1 , Anny Armas Cayarga  1 , Claude Asselin  1   3 , Louis-Charles Fortier  2   3 , Subburaj Ilangumaran  1   3 , Alfredo Menendez  2   3 , Sheela Ramanathan  1   3
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Free article

Interleukin 15 in murine models of colitis

Alicia Molina Kautzman et al. Anat Rec (Hoboken). 2023 May.
Free article

Abstract

Inflammatory bowel diseases (IBDs) are characterized by abnormal, non-antigen specific chronic inflammation of unknown etiology. Genome-wide association studies show that many IBD genetic susceptibility loci map to immune function genes and compelling evidence indicate that environmental factors play a critical role in IBD pathogenesis. Clinical and experimental evidence implicate the pro-inflammatory cytokine IL-15 in the pathogenesis of IBD. IL-15 and IL-15α expression is increased in the inflamed mucosa of IBD patients. IL-15 contributes to the maintenance of different cell subsets in the intestinal mucosa. However, very few studies have addressed the role of IL-15 in pre-clinical models of colitis. In this study, we use three well-characterized models of experimental colitis to determine the contribution of IL-15 to pathological intestinal inflammation.

Keywords: IL-15; Salmonella; colitis.

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