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. 2022;33(6):317-321.
doi: 10.5830/CVJA-2022-030. Epub 2022 Jul 22.

The relationship between gender and systemic immune-inflammation index in patients with new-onset essential hypertension

Emine Altuntas  1 , Sükrü Cetın  2 , Songül Usalp  2
Affiliations

The relationship between gender and systemic immune-inflammation index in patients with new-onset essential hypertension

Emine Altuntas et al. Cardiovasc J Afr. 2022.

Abstract

Aim: The systemic immune-inflammation index (SII) has been reported to have a prognostic ability in various cardiovascular diseases and tumours. In this study, we aimed to investigate whether there was an association between SII and gender and age in newly diagnosed, treatment-naïve, hypertensive patients.

Methods: A total of 153 participants, of whom 93 were men and 60 were women, were included in this retrospective study. Retrospective evaluation of the patients was performed using electronic medical records. The SII was calculated according to the following formula at admission: SII = platelet × neutrophil/lymphocyte counts.

Results: The SII was significantly higher in women compared to men (546.31 vs 385, respectively, p = 0.003) and was positively correlated with age. The receiver operating characteristic curve shows the SII cut-off value predicting new-onset essential hypertension with a sensitivity of 67.6% and a specificity of 67.2% in women.

Conclusions: According to these results, using the SII in cardiovascular diseases may be recommended to increase survival rate in hypertensive women.

Keywords: age; gender; inflammation; newly diagnosed hypertension; systemic immune‐inflammation index.

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Figures

Fig. 1
Fig. 1
Receiver operating characteristic curve to determine the optimal threshold for SII to predict new-onset, essential hypertension in women (AUC: 0.714; p = 0.000; 95% CI: 0.611–0.818; 67.6% sensitivity, 67.2% specificity; SII = 488.21).
See this image and copyright information in PMC

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