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. 2022 Sep 19;61(38):e202208570.
doi: 10.1002/anie.202208570. Epub 2022 Aug 11.

Arene-Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via Glucose Metabolism Reprogramming

Qi-Yuan Yang  1   2 , Rui Ma  1 , Yun-Qiong Gu  1   2 , Xiao-Fang Xu  1 , Zhen-Feng Chen  1 , Hong Liang  1
Affiliations

Arene-Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via Glucose Metabolism Reprogramming

Qi-Yuan Yang et al. Angew Chem Int Ed Engl. .

Abstract

Targeting metabolic reprogramming to treat cancer could increase overall survival and reduce side effects. Here, we put forward a strategy using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming. Complexes 1-6 with oxoglaucine derivatives as ligands were synthesized and their anti-tumor activities were tested under hypoglycemia. Results indicated that 2 and 5 potentiated the anticancer effects of Met. under hypoglycemia, exhibiting lower toxicity, slower blood glucose decline and inhibition of early tumor liver metastasis. Combination of 5 with Met. could be used as a new strategy to treat cancer under hypoglycemia through glucose metabolism reprogramming.

Keywords: Cancer; Glucose Metabolism; Intermittent Fasting; Metformin; Oxoaporphine Arene-Ruthenium(II)/Osmium(II).

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