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. 2022 Jul 28;18(7):e1010669.
doi: 10.1371/journal.ppat.1010669. eCollection 2022 Jul.

Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond

Magnus Ölander  1   2   3 , Barbara S Sixt  1   2   3
Affiliations

Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond

Magnus Ölander et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A timeline for the generation of transformed bacteria in C. trachomatis and E. coli.
Fig 2
Fig 2. The benefits of a versatile genetic toolbox in the exploration of gene functions.
See this image and copyright information in PMC

References

    1. Elwell C, Mirrashidi K, Engel J. Chlamydia cell biology and pathogenesis. Nat Rev Microbiol. 2016;14(6):385–400. doi: 10.1038/nrmicro.2016.30 - DOI - PMC - PubMed
    1. van Schaik EJ, Chen C, Mertens K, Weber MM, Samuel JE. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. Nat Rev Microbiol. 2013;11(8):561–573. doi: 10.1038/nrmicro3049 - DOI - PMC - PubMed
    1. Salje J. Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle. Nat Rev Microbiol. 2021;19(6):375–390. doi: 10.1038/s41579-020-00507-2 - DOI - PubMed
    1. Wang Y, Kahane S, Cutcliffe LT, Skilton RJ, Lambden PR, Clarke IN. Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathog. 2011;7(9):e1002258. doi: 10.1371/journal.ppat.1002258 - DOI - PMC - PubMed
    1. Rachek LI, Tucker AM, Winkler HH, Wood DO. Transformation of Rickettsia prowazekii to rifampin resistance. J Bacteriol. 1998;180(8):2118–2124. doi: 10.1128/JB.180.8.2118-2124.1998 - DOI - PMC - PubMed

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