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Comment
. 2022 Jul 25;57(14):1680-1682.
doi: 10.1016/j.devcel.2022.07.002.

"Fateful" encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression

Wing Hing Wong  1 , Christina Curtis  2
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"Fateful" encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression

Wing Hing Wong et al. Dev Cell. .
Free article

Abstract

In a recent issue of Cell, Yang et al. utilize evolvable cellular barcodes to investigate the evolutionary trajectories of murine lung adenocarcinoma. Reconstructing the life histories of these tumors based on cellular barcodes reveals stringent selection and phenotypic differences across subclonal lineages.

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Conflict of interest statement

Declaration of interests C.C. is an advisor and stockholder in Grail, Ravel, and DeepCell and an advisor to Genentech, Bristol Myers Squibb, 3T Biosciences, and NanoString.

Comment on

  • Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.
    Yang D, Jones MG, Naranjo S, Rideout WM 3rd, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. Yang D, et al. Cell. 2022 May 26;185(11):1905-1923.e25. doi: 10.1016/j.cell.2022.04.015. Epub 2022 May 5. Cell. 2022. PMID: 35523183 Free PMC article.

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