Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004-2020

Abstract

Objectives: To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB).

Design: This was a retrospective cohort study.

Setting: Shandong, China.

Participants: Patients with newly diagnosed TB from 1 January 2004 to 31 December 2020 were collected. Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.

Primary and secondary outcome measures: Patients were classified into four groups including smokers only (G₁), drinker only (G₂), smoker +drinker (G₃), non-smoker +non-drinker group (G₀). We described the drug-resistant profiles, clinical factors and calculated the ORs of different drug-resistance among G₁, G₂, G₃, compared with G₀ through univariate and multivariate logistics regression models.

Results: Of the 7996 TB cases enrolled, the proportions of G₁, G₂, G₃ and G₀ were 8.25%, 3.89%, 16.46% and 71.40%, respectively. The rates of drug-resistant (DR)-TB, mono-resistant TB, multidrug resistant (MDR)-TB, polydrug resistant TB in G_1, G₂, G₃ and G₀ were 19.24%/16.4%/17.33%/19.08%, 11.52%/8.68%/10.94%/11.63%, 3.03%/2.57%/2.96%/3.66% and 4.70%/4.82%/3.34%/ 4.08%, respectively. G₃ had a higher risk of MDR1: isoniazid +rifampin (adjusted OR (aOR)=1.91, 95% CI: 1.036 to 3.532), but had a lower risk of DR-TB (aOR=0.84, 95% CI: 0.71 to 0.99), rifampin-related resistance (aOR=0.68, 95% CI: 0.49 to 0.93), streptomycin-related resistance (aOR=0.82, 95% CI: 0.68 to 0.99), ethambutol-related resistance (aOR=0.57, 95% CI: 0.34 to 0.95), MDR3: isoniazid +rifampin+streptomycin (aOR=0.41, 95% CI: 0.19 to 0.85), any isoniazid +streptomycin resistance (aOR=0.85, 95% CI: 0.71 to 1.00). However, there were no significant differences between G₁ and G₀, G₂ and G₀ in all drug-resistant subtypes. Those patients with cavity had a higher risk of DR-TB among G₃ (OR=1.35, 95% CI: 1.01 to 1.81).

Conclusion: Although we did not found an independent impact of alcohol drinking or tobacco smoking on TB drug-resistance, respectively, these two habits had a combined effect on TB drug-resistance.

Keywords: Respiratory infections; Risk management; Tuberculosis.

Figure 1

Flowchart of the patient inclusion process. NTM, non-tuberculous mycobacterium; PTB, pulmonary tuberculosis; TB, tuberculosis.