Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Jan;41(1):31-32.
doi: 10.1038/s41587-022-01398-9.

BEHAV3D: an imaging and transcriptomics platform that unravels T cell antitumor activity

No authors listed
Comment

BEHAV3D: an imaging and transcriptomics platform that unravels T cell antitumor activity

No authors listed. Nat Biotechnol. 2023 Jan.
No abstract available

PubMed Disclaimer

Comment on

  • Uncovering the mode of action of engineered T cells in patient cancer organoids.
    Dekkers JF, Alieva M, Cleven A, Keramati F, Wezenaar AKL, van Vliet EJ, Puschhof J, Brazda P, Johanna I, Meringa AD, Rebel HG, Buchholz MB, Barrera Román M, Zeeman AL, de Blank S, Fasci D, Geurts MH, Cornel AM, Driehuis E, Millen R, Straetemans T, Nicolasen MJT, Aarts-Riemens T, Ariese HCR, Johnson HR, van Ineveld RL, Karaiskaki F, Kopper O, Bar-Ephraim YE, Kretzschmar K, Eggermont AMM, Nierkens S, Wehrens EJ, Stunnenberg HG, Clevers H, Kuball J, Sebestyen Z, Rios AC. Dekkers JF, et al. Nat Biotechnol. 2023 Jan;41(1):60-69. doi: 10.1038/s41587-022-01397-w. Epub 2022 Jul 25. Nat Biotechnol. 2023. PMID: 35879361 Free PMC article.

References

    1. Chen, D. S. & Mellman, I. Elements of cancer immunity and the cancer-immune set point. Nature 541, 321–330 (2017). A report on the limitations of immunotherapy for solid tumors. - DOI
    1. Hegde, P. S. & Chen, D. S. Top 10 challenges in cancer immunotherapy. Immunity 52, 17–35 (2019). A Perspective article that presents the current challenges in optimization of cancer immunotherapy. - DOI
    1. Tuveson, D. & Clevers, H. Cancer modeling meets human organoid technology. Science 364, 952–955 (2019). A Review discussing the use of organoids as tumor models that recapitulate the original tumor characteristics. - DOI
    1. Ganesh, K. et al. A rectal cancer organoid platform to study individual responses to chemoradiation. Nat. Med. 25, 1607–1614 (2019). A research article showing the potential of organoids for personalized treatment. - DOI
    1. Crainiciuc, G. et al. Behavioural immune landscapes of inflammation. Nature 601, 415–421 (2022). A research article that demonstrates how behavioral profiling can be used to infer immune cell function. - DOI

LinkOut - more resources