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. 2022 Jul 28;22(1):337.
doi: 10.1186/s12872-022-02788-2.

Platelet-hemoglobin ratio predicts amputation in patients with below-knee peripheral arterial disease

Nail Burak Ozbeyaz  1 , Gokhan Gokalp  2 , Engin Algul  3 , Haluk Furkan Sahan  3 , Faruk Aydinyilmaz  4 , Ilkin Guliyev  5 , Kamuran Kalkan  3 , Hilal Erken Pamukcu  3
Affiliations

Platelet-hemoglobin ratio predicts amputation in patients with below-knee peripheral arterial disease

Nail Burak Ozbeyaz et al. BMC Cardiovasc Disord. .

Abstract

Background: Peripheral arterial disease (PAD) causes significant morbidity today. Atherosclerosis is evident in the pathophysiological process in most patients, so PAD has similar risk factors as coronary artery disease. Platelet-Hemoglobin ratio (PHR) has been proven to predict mortality in atherosclerotic heart disease. We aimed to determine the relationship between PHR and below-knee amputation.

Methods: The study is a single-center retrospective study. Platelet count/hemoglobin amount formula was used for PHR. Only PAD patients with below-knee critical extremity ischemia and unsuitable for revascularization were included in the study.

Results: 235 patients were included in the study retrospectively. The mean age was 65.7 ± 9.9 years and 175(74.5%) of them were male. In the amputated group, white blood cell, neutrophil, platelet, creatinine, glucose, and PHR were higher (p = .031, p = .045, p = .011, p = .048 p = .018, p = .004, respectively). Only hemoglobin values were lower (p = .003). Multivariable regression analysis showed; age, albumin and PHR were determined as independent risk factors for amputation (Age; OR (95%CI): (1.094(1.040-1.152), p = .001) (Albumin; OR (95% CI): 1.950(1.623-1.799), p = .001) (PHR; OR (95% CI): 1.872(1.246-2.812), p = .003). Receiver operating characteristics analysis performed to determine the optimal cut-off value of PHR for amputation, the optimal value was found 2.08 (65.8% sensitivity, 67.5% specificity, p < .001).

Conclusions: PHR was a good predictor for BKA. Using the PHR, it may be possible to identify high-risk patients for amputation.

Keywords: Amputation; Below-knee; Peripheral arterial disease; Platelet-hemoglobin ratio.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Displaying platelet-hemoglobin ratio (PHR) with the box-plot table when they are divided into two groups as amputee and non-amputee
Fig. 2
Fig. 2
Receiver operating characteristics (ROC) curve for platelet-hemoglobin ratio (PHR), platelets and hemoglobin in below-knee amputation patients
See this image and copyright information in PMC

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