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Review
. 2022 Jul 28;13(1):366.
doi: 10.1186/s13287-022-03054-0.

Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

Ria Margiana  1   2   3 , Alexander Markov  4   5 , Angelina O Zekiy  6 , Mohammed Ubaid Hamza  7 , Khalid A Al-Dabbagh  8 , Sura Hasan Al-Zubaidi  9 , Noora M Hameed  10 , Irshad Ahmad  11 , R Sivaraman  12 , Hamzah H Kzar  13 , Moaed E Al-Gazally  14 , Yasser Fakri Mustafa  15 , Homayoon Siahmansouri  16
Affiliations
Review

Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

Ria Margiana et al. Stem Cell Res Ther. .

Abstract

The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.

Keywords: Cell therapy; Mesenchymal stromal cell; Regenerative medicine; Stem cell therapy; Tissue regeneration.

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Conflict of interest statement

The authors indicated no potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Effect of bone marrow mesenchymal stem cell-based regenerative medicine
See this image and copyright information in PMC

References

    1. Fugger L, Jensen LT, Rossjohn J. Challenges, progress, and prospects of developing therapies to treat autoimmune diseases. Cell. 2020;181(1):63–80. doi: 10.1016/j.cell.2020.03.007. - DOI - PubMed
    1. Swart JF, et al. Haematopoietic stem cell transplantation for autoimmune diseases. Nat Rev Rheumatol. 2017;13(4):244–256. doi: 10.1038/nrrheum.2017.7. - DOI - PubMed
    1. Abbaszadeh H, et al. Regenerative potential of Wharton's jelly-derived mesenchymal stem cells: a new horizon of stem cell therapy. J Cell Physiol. 2020;235(12):9230–9240. doi: 10.1002/jcp.29810. - DOI - PubMed
    1. Saeedi P, Halabian R, Imani Fooladi AA. A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies. Stem Cell Investig. 2019;6:34. doi: 10.21037/sci.2019.08.11. - DOI - PMC - PubMed
    1. Patel DM, Shah J, Srivastava AS. Therapeutic potential of mesenchymal stem cells in regenerative medicine. Stem Cells Int. 2013;2013:496218. doi: 10.1155/2013/496218. - DOI - PMC - PubMed

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