Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity

doi:10.3389/fimmu.2022.910383

Review

. 2022 Jul 12:13:910383.

doi: 10.3389/fimmu.2022.910383. eCollection 2022.

Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity

Soumya Hunagund¹, Yarden Golan^{2

3}, Ifeyinwa V Asiodu⁴, Mary Prahl^{5

6}, Stephanie L Gaw^{1

7}

Affiliations

¹ Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
² Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.
³ Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, United States.
⁴ Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, United States.
⁵ Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
⁶ Division of Pediatric Infectious Diseases and Global Health, University of California, San Francisco, San Francisco, CA, United States.
⁷ Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.

PMID: 35903100
PMCID: PMC9314549
DOI: 10.3389/fimmu.2022.910383

Review

Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity

Soumya Hunagund et al. Front Immunol. 2022.

. 2022 Jul 12:13:910383.

doi: 10.3389/fimmu.2022.910383. eCollection 2022.

Authors

Soumya Hunagund¹, Yarden Golan^{2

3}, Ifeyinwa V Asiodu⁴, Mary Prahl^{5

6}, Stephanie L Gaw^{1

7}

Affiliations

¹ Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
² Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.
³ Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, United States.
⁴ Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, United States.
⁵ Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
⁶ Division of Pediatric Infectious Diseases and Global Health, University of California, San Francisco, San Francisco, CA, United States.
⁷ Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.

PMID: 35903100
PMCID: PMC9314549
DOI: 10.3389/fimmu.2022.910383

Abstract

Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed.

Keywords: COVID - 19; human milk; immunization; infant health; influenza; pertussis; vaccination.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

1. Wright AL, Holberg CJ, Martinez FD, Morgan WJ, Taussig LM. Breast Feeding and Lower Respiratory Tract Illness in the First Year of Life. Group Health Medical Associates. BMJ (1989) 299:946–9. doi: 10.1136/bmj.299.6705.946 - DOI - PMC - PubMed
1. Pisacane A, Graziano L, Mazzarella G, Scarpellino B, Zona G. Breast-Feeding and Urinary Tract Infection. J Pediatr (1992) 120:87–9. doi: 10.1016/S0022-3476(05)80607-9 - DOI - PubMed
1. Howie PW, Forsyth JS, Ogston SA, Clark A, Florey CD. Protective Effect of Breast Feeding Against Infection. BMJ (1990) 300:11–6. doi: 10.1136/bmj.300.6716.11 - DOI - PMC - PubMed
1. Hanson LA. Breastfeeding Provides Passive and Likely Long-Lasting Active Immunity. Ann Allergy Asthma Immunol (1998) 81:523–33; quiz 533–4, 537. doi: 10.1016/S1081-1206(10)62704-4 - DOI - PubMed
1. Arthur I, Eidelman MD, Schanler MD, Margreete Johnston MD, Susan Landers MD, Larry Noble MD, Kinga Szucs MD, Laura Viehmann MD. Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics (2012) 129:e827–41. doi: 10.1542/peds.2011-3552 - DOI - PubMed

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[1] Wright AL, Holberg CJ, Martinez FD, Morgan WJ, Taussig LM. Breast Feeding and Lower Respiratory Tract Illness in the First Year of Life. Group Health Medical Associates. BMJ (1989) 299:946–9. doi: 10.1136/bmj.299.6705.946 - DOI - PMC - PubMed

[2] Wright AL, Holberg CJ, Martinez FD, Morgan WJ, Taussig LM. Breast Feeding and Lower Respiratory Tract Illness in the First Year of Life. Group Health Medical Associates. BMJ (1989) 299:946–9. doi: 10.1136/bmj.299.6705.946 - DOI - PMC - PubMed

[3] Pisacane A, Graziano L, Mazzarella G, Scarpellino B, Zona G. Breast-Feeding and Urinary Tract Infection. J Pediatr (1992) 120:87–9. doi: 10.1016/S0022-3476(05)80607-9 - DOI - PubMed

[4] Pisacane A, Graziano L, Mazzarella G, Scarpellino B, Zona G. Breast-Feeding and Urinary Tract Infection. J Pediatr (1992) 120:87–9. doi: 10.1016/S0022-3476(05)80607-9 - DOI - PubMed

[5] Howie PW, Forsyth JS, Ogston SA, Clark A, Florey CD. Protective Effect of Breast Feeding Against Infection. BMJ (1990) 300:11–6. doi: 10.1136/bmj.300.6716.11 - DOI - PMC - PubMed

[6] Howie PW, Forsyth JS, Ogston SA, Clark A, Florey CD. Protective Effect of Breast Feeding Against Infection. BMJ (1990) 300:11–6. doi: 10.1136/bmj.300.6716.11 - DOI - PMC - PubMed

[7] Hanson LA. Breastfeeding Provides Passive and Likely Long-Lasting Active Immunity. Ann Allergy Asthma Immunol (1998) 81:523–33; quiz 533–4, 537. doi: 10.1016/S1081-1206(10)62704-4 - DOI - PubMed

[8] Hanson LA. Breastfeeding Provides Passive and Likely Long-Lasting Active Immunity. Ann Allergy Asthma Immunol (1998) 81:523–33; quiz 533–4, 537. doi: 10.1016/S1081-1206(10)62704-4 - DOI - PubMed

[9] Arthur I, Eidelman MD, Schanler MD, Margreete Johnston MD, Susan Landers MD, Larry Noble MD, Kinga Szucs MD, Laura Viehmann MD. Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics (2012) 129:e827–41. doi: 10.1542/peds.2011-3552 - DOI - PubMed

[10] Arthur I, Eidelman MD, Schanler MD, Margreete Johnston MD, Susan Landers MD, Larry Noble MD, Kinga Szucs MD, Laura Viehmann MD. Section on Breastfeeding. Breastfeeding and the Use of Human Milk. Pediatrics (2012) 129:e827–41. doi: 10.1542/peds.2011-3552 - DOI - PubMed

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Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity

Affiliations

Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity

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