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Review
. 2022 Jul 12:12:962782.
doi: 10.3389/fcimb.2022.962782. eCollection 2022.

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

Jingyi Chen  1 , Yu Wang  1 , Yongxia Shi  2 , Yongpan Liu  1 , Chengyi Wu  1 , Yanrong Luo  3
Affiliations
Review

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

Jingyi Chen et al. Front Cell Infect Microbiol. .

Abstract

Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical practice with a high mortality rate. However, there is still a lack of effective prevention and treatment measures for II/R injury. The role of the gut microbiota in II/R has attracted widespread attention. Recent evidence has demonstrated that the gut microbiota plays a pivotal role in the occurrence, development, and prognosis of II/R. Therefore, maintaining the homeostasis of gut microbiota and its metabolites may be a potential strategy for the treatment of II/R. This review focuses on the importance of crosstalk between the gastrointestinal ecosystem and II/R to highlight II/R-induced gut microbiota signatures and potential applications of microbial-based therapies in II/R. This will also provide potentially effective biomarkers for the prediction, diagnosis and treatment of II/R.

Keywords: biomarkers; intestinal dysbiosis; intestinal ischemia reperfusion; intestinal microbiota; metabolites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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